Lung cancer susceptibility and polymorphisms of glutathione-S-transferase genes in Hong Kong

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Moira Chan-YeungWah Kit Lam

Abstract

To study the potential role of genetic polymorphisms of glutathione-S-transferases GSTM1, GSTT1 and GSTP1 in susceptibility to lung cancer in Hong Kong Chinese. 229 consecutive incident patients with a histological diagnosis of lung cancer from a regional hospital and 197 healthy population-based controls were recruited for this study between July 1999 and June 2001. Genetic polymorphisms of GSTT1 and GSTM1 were determined using PCR-based technique. The frequencies of GSTT1 and GSTM1 null genotypes were 51.8 and 59.4% in healthy controls and 63 and 54.7%, respectively, in lung cancer patients. GSTP1 Val105/Val105 genotype was found in only 1% of healthy controls. The risk for lung cancer with GSTT1 null genotype was significantly higher, adjusted odds ratio (OR) 1.69, 95% confidence interval (CI) 1.12-2.56, compared with those with the GSTT1 genotype; the increase in risk was found only in non-smokers. GSTM1 null genotype, combined GSTT1 and GSTM1 null genotype and GSTP1 Val105/Val105 genotype did not confer any increase risk for lung cancer. GSTT1 null genotype is associated with an increased risk for lung cancer in non-smoking Chinese in Hong Kong.

References

Feb 15, 1992·The Biochemical Journal·B MannervikW R Pearson
Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Feb 15, 1985·International Journal of Cancer. Journal International Du Cancer·L C KooN Lee
Jan 22, 1998·Mutation Research·R el-ZeinW W Au
Jul 29, 1998·International Journal of Cancer. Journal International Du Cancer·S T SaarikoskiA Hirvonen
Apr 21, 1999·International Journal of Cancer. Journal International Du Cancer·I PerssonM Ingelman-Sundberg
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·Frank D GillilandRob McConnell

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Citations

Jul 17, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaogang ChenYu Chen
Jun 25, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qian GuiXiaoye Lu
Feb 26, 2009·American Journal of Epidemiology·Michele L CoteEmanuela Taioli
Aug 24, 2010·Pharmacogenetics and Genomics·Scott M LangevinUNKNOWN Genetic Susceptibility to Environmental Carcinogens group (GSEC)
Sep 2, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Wah Kit Lam
Oct 31, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Moira Chan-YeungUNKNOWN Hong Kong Thoracic Society
Aug 1, 2012·Environmental Health Perspectives·Britt C ReidLinda S Birnbaum
Nov 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hongmei YangRui Ma
Apr 18, 2013·Blood Cells, Molecules & Diseases·Romério Alencar de Oliveira FilhoRosângela Ferreira Frade de Araújo
Dec 6, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Dan J RazDavid M Jablons
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·James C HoMoira Chan-Yeung
Sep 29, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xiuquan ShiZengzhen Wang
Dec 23, 2006·Risk Analysis : an Official Publication of the Society for Risk Analysis·Louis Anthony Tony Cox
Jul 27, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J C W MakM Chan-Yeung
Mar 6, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Peter GresnerWojciech Wasowicz
Jan 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Hong-Zhou LiuMing-Jun Han
Jun 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·R K ShuklaS Bhattacharya
Oct 9, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Xin-Ping ChenSheng-Miao Fu
Apr 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan ZhaoWeiquan Lu
Jul 26, 2011·Respiratory Medicine·Sanctus MusafiriClaver Rutayisire
Jul 19, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiaomin LiuGuoguo Li
Aug 12, 2009·Molecular Biology Reports·Julide AltinisikNur Buyru

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