Lung Cancer-Targeting Peptides with Multi-subtype Indication for Combinational Drug Delivery and Molecular Imaging

Theranostics
Yi-Hsuan ChiHan-Chung Wu

Abstract

Lung cancer is the leading cause of cancer-related death worldwide. Most targeted drugs approved for lung cancer treatment are tyrosine kinase inhibitors (TKIs) directed against EGFR or ALK, and are used mainly for adenocarcinoma. At present, there is no effective or tailored targeting agent for large cell carcinoma (LCC) or small cell lung cancer (SCLC). Therefore, we aimed to identify targeting peptides with diagnostic and therapeutic utility that possess broad subtype specificity for SCLC and non-small cell lung cancer (NSCLC). We performed phage display biopanning of H460 LCC cells to select broad-spectrum lung cancer-binding peptides, since LCC has recently been categorized as an undifferentiated tumor type within other histological subcategories of lung cancer. Three targeting phages (HPC1, HPC2, and HPC4) and their respective displayed peptides (HSP1, HSP2, and HSP4) were able to bind to both SCLC and NSCLC cell lines, as well as clinical specimens, but not to normal pneumonic tissues.In vivooptical imaging of phage homing and magnetic resonance imaging (MRI) of peptide-SPIONs revealed that HSP1 was the most favorable probe for multimodal molecular imaging. Using HSP1-SPION, the T2-weighted MR signal of H460 xenografts w...Continue Reading

Citations

Jul 24, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Wei WangYue-Yin Pan
Nov 12, 2019·Frontiers in Pharmacology·Vijay Sagar MadamsettySudip Mukherjee
May 1, 2019·Cancers·Anubhab MukherjeeSudip Mukherjee
Dec 21, 2020·Current Opinion in Pharmacology·Mohammad DoroudianSeamas C Donnelly
May 22, 2021·Advanced Healthcare Materials·Shilin LiYing Liu
Jul 3, 2021·Pharmaceuticals·Bryan GibbChristine L Schneider
Apr 27, 2020·Current Radiopharmaceuticals·Selin Soyluoglu, Gulay Durmus-Altun

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Methods Mentioned

BETA
X-ray
biopsy
phage display
ELISA
flow cytometry
fluorescence-activated cell sorting
light microscopy
xenografts
xenograft
fluorescence imaging

Software Mentioned

MRVision
Living Image
Avizo

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