Aug 2, 2011

Lung carcinoma signaling pathways activated by smoking

Chinese Journal of Cancer
Jing WenMing Guo


Lung cancer is the leading cause of cancer death in men and women worldwide, with over a million deaths annually. Tobacco smoke is the major etiologic risk factor for lung cancer in current or previous smokers and has been strongly related to certain types of lung cancer, such as small cell lung carcinoma and squamous cell lung carcinoma. In recent years, there has been an increased incidence of lung adenocarcinoma. This change is strongly associated with changes in smoking behavior and cigarette design. Carcinogens present in tobacco products and their intermediate metabolites can activate multiple signaling pathways that contribute to lung cancer carcinogenesis. In this review, we summarize the smoking-activated signaling pathways involved in lung cancer.

  • References63
  • Citations11


  • References63
  • Citations11


Mentioned in this Paper

Biochemical Pathway
Adenocarcinoma of Lung (Disorder)
Small Cell Carcinoma of Lung
Carcinoma of Lung
Beta-adrenergic receptor
Epidermal Growth Factor Receptor
Squamous Cell Carcinoma
Squamous Cell Carcinoma of Lung

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