Lung deposition after inhalation with various nebulisers in preterm infants

Archives of Disease in Childhood. Fetal and Neonatal Edition
E KöhlerG Jorch

Abstract

To compare pulmonary deposition after inhalation with three different nebulisers in preterm infants under conditions relevant to practice. The relative lung deposition (bioavailability) was estimated by inhalation of the marker substance, sodium cromoglycate (SCG), and measurement of urinary excretion of SCG. Seventeen spontaneously breathing preterm infants received 20 mg of SCG as nebuliser solution by means of (a) an LC Star jet nebuliser; (b) an LS 290 ultrasonic nebuliser; and (c) a Projet ultrasonic nebuliser in a randomised three-period, crossover design. Serial urine samples were collected until about 12 hours after inhalations, and the excreted SCG was determined by high-performance liquid chromatography. The mean (SD) total amounts of SCG excreted in urine measured after inhalation with the LC Star nebuliser (0.089 (0.036) mg) were significantly higher than those obtained with the LS 290 (0.055 (0.019) mg) or the Projet nebuliser (0.046 (0.025) mg). The average pulmonary deposition after inhalation using the LC Star, LS 290 and Projet devices was estimated as 0.89%, 0.55% and 0.46% of the nominal dose, respectively. Inhalation with the LC Star jet nebuliser producing the greatest proportion of droplets <2 mum yielded ...Continue Reading

Citations

Sep 30, 2010·European Journal of Pediatrics·Jan Mazela, Richard A Polin
Nov 3, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Xabier MurgiaCarmen Rey-Santano
Jan 1, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Sybrich TiemersmaSunalene G Devadason
Jul 28, 2011·Journal of Asthma and Allergy·Gavin Dalglish, Graham Priestley
Sep 6, 2014·PloS One·Jonathan L SlaughterSudarshan R Jadcherla
Mar 27, 2010·The Journal of Allergy and Clinical Immunology·Israel AmiravKaren G Schüepp
Mar 3, 2018·International Journal of Environmental Research and Public Health·Iñigo AramendiaMiguel Angel Gomez-Solaetxe
Jan 10, 2019·Pharmaceutics·Iñigo AramendiaMiguel Angel Gomez-Solaetxe
Aug 8, 2015·Clinical Pharmacokinetics·Matthew W LinakisCatherine M T Sherwin
Feb 28, 2021·Respiratory Research·Federico BiancoJane Pillow
Jun 3, 2021·Pharmaceutics·Felix C WiegandtGerhard Pohlmann
Jul 3, 2021·Children·Mandy BrasherElie G Abu Jawdeh
Jul 25, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Alberto HidalgoJesus Perez-Gil

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