Lung deposition of fenoterol and flunisolide delivered using a novel device for inhaled medicines: comparison of RESPIMAT with conventional metered-dose inhalers with and without spacer devices.

Chest
S P NewmanH Kladders

Abstract

To compare lung deposition of fenoterol or flunisolide administered from a novel, multidose inhalation device delivering liquid droplets (RESPIMAT; Boehringer Ingelheim Ltd; Bracknell, UK) or from conventional metered-dose inhalers (MDIs) with and without spacers. Two randomized, three-way crossover studies. Clinical research laboratory. Healthy, nonsmoking volunteers. In one study, radiolabeled aerosols of fenoterol from the RESPIMAT device and from a conventional MDI with or without an Aerochamber spacer (Trudell Medical; London, Ontario Canada). In the second study, radiolabeled aerosols of flunisolide from a RESPIMAT device, from a RESPIMAT device modified by inclusion of a baffle/impactor in the mouthpiece, and from a conventional MDI with an Inhacort spacer (Boehringer Ingelheim; Ingelheim, Germany). Assessment of the deposition of fenoterol or flunisolide in the lung and oropharynx using gamma scintigraphy. Safety was assessed based on reported adverse effects and spirometry (FEV1, FVC, and peak expiratory flow rate) to detect any paradoxical bronchoconstriction. The RESPIMAT device delivered significantly more fenoterol to the lungs than either an MDI alone or an MDI with Aerochamber (39.2% vs 11.0% and 9.9% of metered ...Continue Reading

References

Jan 1, 1992·European Journal of Nuclear Medicine·S S DavisI R Wilding
Apr 1, 1991·Thorax·H L AshworthJ G Hardy
Jul 1, 1988·Age and Ageing·J M Armitage, S J Williams
Aug 1, 1995·The Journal of Allergy and Clinical Immunology·E R McFadden
Oct 1, 1994·Respiratory Medicine·M R Partridge
Aug 1, 1994·Clinical Pharmacokinetics·J C VirchowH Matthys
Feb 1, 1996·Respiratory Medicine·S Pedersen
Mar 1, 1996·Postgraduate Medical Journal·P L AriyanandaS W Clarke
Sep 1, 1996·Journal of Pharmaceutical Sciences·S P NewmanB Zierenberg
Mar 1, 1993·The European Respiratory Journal·P H QuanjerJ C Yernault

❮ Previous
Next ❯

Citations

Dec 18, 2010·Revue des maladies respiratoires·A-C HenrietP Diot
Jul 5, 2003·Advanced Drug Delivery Reviews·Stephen P NewmanLisa Rankin
Nov 7, 2000·International Journal of Pharmaceutics·S P NewmanP H Hirst
Apr 25, 2001·British Journal of Clinical Pharmacology·H Chrystyn
Jun 27, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·H DerendorfH Möllmann
Oct 30, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·J RichardsS P Newman
Jan 6, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·S P Newman
Jan 6, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·M Dolovich
Sep 27, 2005·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Rajiv Dhand
Sep 27, 2005·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Gary PitcairnSteve Newman
Sep 27, 2005·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Dieter HochrainerHerbert Wachtel
Mar 29, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Stephen P NewmanAnil K Sohal
Oct 30, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·P Worth Longest, Michael Hindle
Aug 30, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Dominic DellwegThomas Glaab
Jan 28, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Andrew R Clark
Jan 5, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Geng TianMichael Hindle
Dec 1, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Paula Anderson
Aug 5, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Rick HodderEric Bateman
May 24, 2012·International Journal of Nanomedicine·Paul ZarogoulidisKonstantinos Zarogoulidis
Jan 1, 2011·Medical Devices : Evidence and Research·Richard N DalbyBernd Zierenberg
Jun 10, 2003·Clinical Pharmacokinetics·Stephen P Newman
Feb 24, 2005·Treatments in Respiratory Medicine·Chris M KozmaPat R Reese
Jun 26, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Rick HodderTerra Slaton
Aug 18, 2010·International Journal of Chronic Obstructive Pulmonary Disease·Eric BatemanRick Hodder
Feb 18, 2006·Respiration; International Review of Thoracic Diseases·K R PatelM Spiteri
Aug 31, 2007·Respiration; International Review of Thoracic Diseases·V LeclercD Pavia
Jul 30, 2008·Drug Development and Industrial Pharmacy·Alan B WattsRobert O Williams
Nov 22, 2005·Expert Opinion on Drug Delivery·Zia R Tayab, Günther Hochhaus
Sep 6, 2005·Current Medical Research and Opinion·Helgo Magnussen
Jan 30, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Nicolas Roche, P N Richard Dekhuijzen
Jan 1, 2013·Pulmonary Pharmacology & Therapeutics·Mario CazzolaMaria Gabriella Matera
Jun 7, 2011·International Journal of Pharmaceutics·Jennifer WalshUNKNOWN European Paediatric Formulation Initiative (EuPFI)
Dec 17, 2009·The Journal of Allergy and Clinical Immunology·Paul M O'ByrneLouis-Philippe Boulet
Sep 15, 2004·International Journal of Pharmaceutics·R DalbyT Voshaar
May 7, 2015·Pharmaceutical Research·Geng TianP Worth Longest
Sep 6, 2005·Current Medical Research and Opinion·J Christian Virchow
Apr 15, 2010·Inhalation Toxicology·Ahmed FadlZongqin Zhang
Oct 16, 2004·Respiratory Medicine·J Christian Virchow
Feb 23, 2010·Respiratory Medicine·R ZuwallackUNKNOWN Combivent Respimat Inhaler Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.