Lung deposition of nebulized surfactant in newborn piglets

Neonatology
Rikard LinnerDoris Cunha-Goncalves

Abstract

It would be advantageous for the treatment of neonatal respiratory distress syndrome if effective amounts of surfactant could be delivered by nebulization. To investigate lung deposition and distribution of nebulized porcine surfactant using an investigational eFlow neonatal nebulizer. While lying on one side, 1-day-old piglets inhaled 200 mg·kg(-1) of nebulized surfactant via mask, nasal prongs, or tracheal tube. The surfactant was diluted with normal saline to 40 mg·ml(-1) and labeled with (99m)technetium-labelled nanocolloid. Undiluted surfactant (80 mg·ml(-1)) was instilled tracheally in a fourth group. Each group had 8 animals. Lung deposition was measured by gamma scintigraphy, and deposition values were presented as a percentage of the nebulized or instilled dose. The median lung deposition of inhaled surfactant was 5% (range 3-16) via mask, 14% (2-40) via prongs, and 45% (25-56) via tracheal tube (p < 0.05). It was 88% (71-96) with instillation. In all groups, the surfactant preferentially went to the dependent lung. Deposition ratios (upper lung/both lungs) were 0.32 (0.13-0.58), 0.15 (0.05-0.58), 0.16 (0.11-0.23), and 0.08 (0.03-0.46). Using this nebulizer, the lung depositions of porcine surfactant were 45% via endot...Continue Reading

Citations

Dec 14, 2019·Pediatric Pulmonology·Anders NordValeria Perez-de-Sa
Mar 21, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Carmen Rey-SantanoBegoña Loureiro
Jul 28, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Stefan MinocchieriUNKNOWN CureNeb Study Team
Aug 8, 2020·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Connor HoweP Worth Longest
May 28, 2020·Frontiers in Pediatrics·Ibrahim Sammour, Sreenivas Karnati
Feb 28, 2021·Respiratory Research·Federico BiancoJane Pillow
May 8, 2021·Pediatric Pulmonology·Carmen Rey-SantanoMiguel Angel Gomez-Solaetxe

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