Lung dysfunction causes systemic hypoxia in estrogen receptor beta knockout (ERbeta-/-) mice.

Proceedings of the National Academy of Sciences of the United States of America
Andrea MoraniJan-Ake Gustafsson

Abstract

Estrogen receptor beta (ERbeta) is highly expressed in both type I and II pneumocytes as well as bronchiolar epithelial cells. ERalpha is not detectable in the adult lung. Lungs of adult female ERbeta knockout (ERbeta-/-) mice have already been reported to have fewer alveoli and reduced elastic recoil. In this article, we report that, by 5 months of age, there are large areas of unexpanded alveoli in lungs of both male and female ERbeta-/- mice. There is increased staining for collagen and, by EM, abnormal clusters of collagen fibers are seen in the alveolar septa of ERbeta-/- mice. Immunohistochemical analysis and Western blotting with lung membrane fractions of ERbeta-/- mice revealed down-regulation of caveolin-1, increased expression of membrane type-1 metalloproteinase, matrix metalloproteinase 2 (active form), and tissue inhibitors of metalloproteinases 2. Hypoxia, measured by immunohistochemical analysis for hypoxia-inducible factor 1alpha and chemical adducts (with Hypoxyprobe), was evident in the heart, ventral prostate, periovarian sac, kidney, liver, and brain of ERbeta-/- mice under resting conditions. Furthermore, both male and female adult ERbeta-/- mice were reluctant to run on a treadmill and tissue hypoxia beca...Continue Reading

References

Dec 1, 1990·British Journal of Cancer·J M ClineJ A Raleigh
Feb 21, 1992·Cell·K G RothbergR G Anderson
Jun 1, 1990·Baillière's Clinical Endocrinology and Metabolism·C R Mendelson, V Boggaram
May 1, 1989·Endocrine Reviews·P L Ballard
Jul 1, 1993·American Journal of Respiratory Cell and Molecular Biology·M G ArdenI Y Adamson
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson
May 1, 1996·Kidney International·N D Vaziri, Z Q Wang
Mar 1, 1997·International Journal of Radiation Oncology, Biology, Physics·A S KennedyM A Varia
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·J H KregeO Smithies
Feb 15, 2001·The Biochemical Journal·B AnnabiR Béliveau
Nov 1, 2001·Respiratory Research·W C Parks, S D Shapiro
Nov 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Carola FörsterJan-Ake Gustafsson
Nov 27, 2002·The European Respiratory Journal·M T HenryC M O'Connor
Mar 1, 2003·Pathology International·Mohammed S Razzaque, Takashi Taguchi
Nov 13, 2003·Molecular and Cellular Biology·Cesare PatroneMagnus Nord
May 20, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Michael K SamoszukEugene Mechetner
Jun 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Otabek ImamovJan-Ake Gustafsson
Aug 10, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Donald Massaro, Gloria Decarlo Massaro
Sep 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Carola FörsterJan-Ake Gustafsson
Mar 2, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jeffrey J AtkinsonRobert M Senior
Jul 16, 2005·Experimental Lung Research·Subhadeep Chakrabarti, Kamala D Patel
Oct 18, 2005·Thorax·P T G Elkington, J S Friedland
Jan 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Rodrigo P A BarrosJan-Ake Gustafsson
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Osamu Wada-HiraikeJan-Ake Gustafsson

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Citations

Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Maria Cristina AntalManuel Mark
Nov 28, 2007·Molecular and Cellular Biology·Wen CaiIngemar Pongratz
Jan 20, 2009·American Journal of Respiratory and Critical Care Medicine·Donald C McCurninPhilip W Shaul
Jul 5, 2012·Endocrinology·Christopher D HainesLeslie A Leinwand
Dec 25, 2008·Molecular Endocrinology·Guangfeng ZhangHarish Srinivas
Sep 3, 2010·Molecular Endocrinology·Ali PedramEllis R Levin
Apr 25, 2012·Medicine and Science in Sports and Exercise·Espen E SpangenburgDawn A Lowe
Jan 2, 2013·Frontiers in Bioscience (Scholar Edition)·Pandu R GangulaDiane Moseberry
Nov 15, 2014·Lung Cancer Management·Timothy F Burns, Laura P Stabile
May 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Otabek ImamovJan-Ake Gustafsson
Dec 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xiaotang FanJan-Ake Gustafsson
Nov 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Osamu Wada-HiraikeJan-Ake Gustafsson
Feb 26, 2014·Seminars in Oncology·Jill M Siegfried, Laura P Stabile
Apr 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Laure ManeixJan-Åke Gustafsson
Jun 19, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hanna Drzewiecka, Paweł P Jagodzinski
Jul 26, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Marco MarzioniStefan Nilsson
Apr 23, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Vei MahLee Goodglick
Oct 26, 2010·Trends in Endocrinology and Metabolism : TEM·Tommy SeabornYves Tremblay
Dec 10, 2009·Seminars in Oncology·Jill M SiegfriedLaura P Stabile
May 13, 2009·Molecular and Cellular Endocrinology·Margarita M IvanovaCarolyn M Klinge
May 15, 2015·The Journal of Toxicological Sciences·Junko KurokawaTetsushi Furukawa
Aug 17, 2012·The Journal of Investigative Dermatology·Margaret MarkiewiczMaria Trojanowska
Mar 3, 2009·Annals of the New York Academy of Sciences·Diana C Márquez-GarbánRichard J Pietras
Jun 28, 2013·British Journal of Pharmacology·K M MairM R MacLean
Jan 18, 2015·Pharmacology & Therapeutics·Venkatachalem SathishY S Prakash
Mar 15, 2015·Cardiovascular Research·Audrey F WrightMargaret R Maclean
May 28, 2013·Molecular and Cellular Endocrinology·Konstantin YakimchukSam Okret
Jun 7, 2011·The American Journal of Pathology·Rachel L LeonCharles L Rosen
Jun 22, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Vanessa W LimEu Leong Yong
May 11, 2016·Molecular and Cellular Endocrinology·Emily K PugachLeslie A Leinwand
Oct 27, 2016·Molecular Biology Reports·Bartosz Kazimierz SłowikowskiPaweł Piotr Jagodziński
Jan 26, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Elke Dworatzek, Shokoufeh Mahmoodzadeh
May 19, 2017·Endocrinology·M A Karim RumiMichael J Soares
Jan 1, 2012·Cancers·Christina S Baik, Keith D Eaton
Aug 8, 2017·International Journal of Molecular Sciences·Li-Han HsuShu-Huei Kao
Aug 19, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Chiara BolegoAndrea Cignarella

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