Lung eosinophilic inflammation and airway hyperreactivity are enhanced by murine anaphylactic, but not nonanaphylactic, IgG1 antibodies

The Journal of Allergy and Clinical Immunology
Maria Fernanda Macedo-SoaresMahasti S Macedo

Abstract

Chronic airway inflammation is a fundamental feature of bronchial asthma, which is characterized by the accumulation and activation of inflammatory cells, such as mast cells and eosinophils, that are tightly regulated by TH2 cytokines and chemokines. Recently, we demonstrated, in a murine model of asthma with immunosuppressed mice reconstituted with antigen-specific IgE or IgG1 antibodies, that IgE, but not IgG1, participates in potentiation of airway inflammation and induction of airway hyperreactivity (AHR). The IgG1 antibody, however, did not elicit passive cutaneous anaphylactic reactions, which was in contrast to IgE. Because 2 types of murine IgG1 have been demonstrated with regard to anaphylactic activity, the present experiments were undertaken to determine the role of anaphylactic and nonanaphylactic IgG1 antibodies in the development of antigen-induced eosinophilia and AHR in this model. Dinitrophenyl-conjugated, heat-coagulated hen's egg white was implanted in immunosuppressed mice reconstituted with anaphylactic or nonanaphylactic IgG1. Intratracheal challenge with aggregated dinitrophenyl-ovalbumin was performed on day 14, and lung inflammatory and mechanical parameters were evaluated after 48 hours. Our results de...Continue Reading

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Citations

Jun 29, 2006·International Archives of Allergy and Immunology·Aldacilene S SilvaMahasti S Macedo
Sep 30, 2005·American Journal of Respiratory and Critical Care Medicine·Shigeki MatsubaraErwin W Gelfand
Sep 7, 2013·PLoS Neglected Tropical Diseases·Natalie E NieuwenhuizenAndreas L Lopata
Nov 4, 2010·Scandinavian Journal of Immunology·C A A de AraújoM F Macedo-Soares
Feb 8, 2006·The Journal of Allergy and Clinical Immunology·Alexandre C KellerMomtchilo Russo
Sep 2, 2005·The Korean Journal of Internal Medicine·Yoon-Seok ChangYou-Young Kim
Jun 30, 2009·Experimental Dermatology·Franziska BubackJohannes M Weiss
Jul 13, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D M ItamiM F Macedo-Soares
Apr 10, 2017·Inflammation·Renata Tiscoski NesiSamuel Santos Valença
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chandra Shekhar BakshiTimothy J Sellati

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