Lung epithelial-C/EBPβ contributes to LPS-induced inflammation and its suppression by formoterol

Biochemical and Biophysical Research Communications
Abraham B RoosMagnus Nord

Abstract

The inflammatory processes associated with pulmonary disorders remains incompletely understood. CCAAT/enhancer-binding protein (C/EBP)β is implicated in inflammatory lung disorders as well as in β(2)-adrenoceptor signaling. We hypothesized that C/EBPβ in the lung epithelium contributes to lipopolysaccharide (LPS)-induced airway neutrophilia and expression of neutrophil chemoattractant chemokine (C-X-C) motif ligand (CXCL)1, as well as the suppressive effects of long-acting β(2)-agonists (LABAs) and glucocorticoids (GCs). To investigate this, mice with a lung epithelial-specific deletion of C/EBPβ (Cebpb(ΔLE)) and control littermates (Cebpb(fl/fl)) were pre-treated with a LABA, formoterol and/or a GC, budesonide, and challenged with LPS. Inflammatory cell recruitment in bronchoalveolar lavage (BAL) fluid and pulmonary expression of inflammatory mediators were investigated. In addition, the ability of formoterol to increase C/EBP transactivation was assessed in vitro. LPS-challenged Cebpb(ΔLE) mice exhibited fewer BAL neutrophils and lower pulmonary expression of CXCL1 versus Cebpb(fl/fl) mice. Suppression of LPS-induced neutrophilia by formoterol was impaired in Cebpb(ΔLE) mice and Cxcl1 expression was increased. However, suppre...Continue Reading

References

May 24, 2001·The Journal of Biological Chemistry·C NirodiA Richmond
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·S J WilsonS T Holgate
May 15, 2002·The Biochemical Journal·Dipak P Ramji, Pelagia Foka
Jun 8, 2002·Biochemical and Biophysical Research Communications·Tove BergMagnus Nord
Sep 10, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tobias N Cassel, Magnus Nord
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryan E WileyManel Jordana
Jul 13, 2005·Biochemical and Biophysical Research Communications·Tove BergMagnus Nord
Jun 15, 2006·The European Respiratory Journal·M A Giembycz, R Newton
Jan 19, 2007·Respiratory Medicine·Karin StrandbergKjell Larsson
Feb 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jae-Woo KimM Daniel Lane
Mar 31, 2007·The Journal of Biological Chemistry·Michael R EdwardsSebastian L Johnston
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Klaus F RabeUNKNOWN Global Initiative for Chronic Obstructive Lung Disease
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ning ZhangRobert P Schleimer
Apr 12, 2008·American Journal of Respiratory and Critical Care Medicine·Jacobien J HoogerwerfTom van der Poll
Apr 19, 2008·American Journal of Respiratory Cell and Molecular Biology·Ida A J GiebelenTom van der Poll
Sep 1, 2009·American Journal of Respiratory Cell and Molecular Biology·Peter J Barnes
Nov 17, 2010·Pharmacological Reviews·Brice KorkmazFrancis Gauthier
May 13, 2011·American Journal of Respiratory and Critical Care Medicine·Lukas DidonMagnus Nord
Jun 18, 2011·American Journal of Respiratory and Critical Care Medicine·Mona BafadhelChristopher E Brightling
Mar 14, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Abraham B RoosMagnus Nord

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Citations

Oct 30, 2015·Respiratory Research·Michiko MoriAbraham B Roos
Aug 31, 2018·Journal of Oral Science·Keisuke NodaYorimasa Ogata

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