Lung epithelium: barrier immunity to inhaled fungi and driver of fungal-associated allergic asthma

Current Opinion in Microbiology
Darin L Wiesner, Bruce S Klein

Abstract

Fungi are ubiquitous in the environment. The epithelium that lines our airways is the first point of contact with the frequent encounter of inhaled fungi. Consequently, the lung epithelium has evolved behaviors that instruct the earliest immune events to resist fungal penetration. Although the epithelium efficiently assists in immunity to invasive fungi, it also can be inappropriately triggered, to the detriment of the host, by normally innocuous fungi or fungal components. Thus, there is a tipping point of protective immunity against fungal pathogens versus inflammatory disease caused by an exuberant immune response to harmless fungal antigens. This review will discuss several aspects of barrier immunity to pulmonary fungal infection, as well as situations where fungal exposure leads to allergic asthma.

Citations

Feb 22, 2018·Journal of Fungi·Steven T Denham, Jessica C S Brown
May 22, 2018·Immunology·Andrew J McDermott, Bruce S Klein
Sep 22, 2018·Medical Mycology·Sara GagoPaul Bowyer
Aug 19, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Eva-Maria RickCatherine H Pashley
Oct 18, 2019·Clinical Microbiology Reviews·Fariba M DonovanJohn N Galgiani
Sep 22, 2018·Nature Communications·Sara GagoPaul Bowyer
Jun 7, 2019·International Journal of Molecular Sciences·Ryoji ItoSatoshi Nunomura
Sep 10, 2020·Frontiers in Veterinary Science·Laurent CouetilCyprianna Swiderski
Oct 20, 2020·Frontiers in Immunology·Derry K Mercer, Deborah A O'Neil
Feb 25, 2021·Journal of Proteomics·Sangeeta RoySwati Gupta Bhattacharya
Mar 5, 2020·Cell Host & Microbe·Darin L WiesnerBruce S Klein
Jun 3, 2021·International Forum of Allergy & Rhinology·Matthew A TylerAmber U Luong

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