Lung Function and Gene Expression of Pathogen Recognition Pathway Receptors: the Cardia Lung Study.

Scientific Reports
Ramya RamasubramanianBharat Thyagarajan

Abstract

Activation of toll-like receptors (TLR1, TLR5, TLR6) and downstream markers (CCR1, MAPK14, ICAM1) leads to increased systemic inflammation. Our objective was to study the association between the gene expression levels of these six genes and lung function (Forced Expiratory Volume in one second (FEV1), Forced Vital Capacity (FVC) and FEV1/FVC). We studied gene expression levels and lung function in the Coronary Artery Risk Development in Young Adults study. Spirometry testing was used to measure lung function and gene expression levels were measured using the Nanostring platform. Multivariate linear regression models were used to study the association between lung function measured at year 30, 10-year decline from year 20 to year 30, and gene expression levels (highest quartile divided into two levels - 75th to 95th and>95th to 100th percentile) adjusting for center, smoking and BMI, measured at year 25. Year 30 FEV1 and FVC were lower in the highest level of TLR5 compared to the lowest quartile with difference of 4.00% (p for trend: 0.04) and 3.90% (p for trend: 0.05), respectively. The 10-year decline of FEV1 was faster in the highest level of CCR1 as compared to the lowest quartile with a difference of 1.69% (p for trend: 0.0...Continue Reading

References

Jan 1, 1988·Journal of Clinical Epidemiology·G D FriedmanP J Savage
Dec 24, 1997·American Journal of Epidemiology·H J SchünemannM Trevisan
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Feb 17, 2000·Cellular Signalling·K Ono, J Han
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·M DahlB G Nordestgaard
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Veit HornungGunther Hartmann
Oct 15, 2003·Clinical Microbiology Reviews·S Janssens, R Beyaert
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisa C ParkerIan Sabroe
Sep 1, 2004·The Journal of Biological Chemistry·Steven BlackDavid Samols
Sep 30, 2004·Nature Immunology·Akiko Iwasaki, Ruslan Medzhitov
Jul 1, 2005·Treatments in Respiratory Medicine·Irfan Rahman
Oct 21, 2005·Chest·Gavin C DonaldsonJadwiga A Wedzicha
Dec 13, 2005·The Journal of Allergy and Clinical Immunology·Kawa AminGunnar Nilsson
Mar 24, 2006·International Journal of Epidemiology·Bharat ThyagarajanO Dale Williams
May 3, 2006·Respiratory Medicine·Rafea ShaabanMahmoud Zureik
Jul 3, 2007·Thorax·Robert J HancoxMalcolm R Sears
Aug 8, 2007·Immunology and Cell Biology·Simon PhippsKlaus I Matthaei
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philippe JoubertQutayba Hamid
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbara KollerDominik Hartl
Jul 2, 2010·Allergy, Asthma & Immunology Research·You Sook Cho, Hee-Bom Moon
Feb 22, 2012·Science·Sung-il YoonIan A Wilson
Mar 13, 2012·Pharmacological Reviews·Gillina F G BezemerGert Folkerts
May 9, 2012·Frontiers in Immunology·Laura Oliveira-NascimentoLee M Wetzler
Sep 26, 2013·Mucosal Immunology·L Van MaeleJ-C Sirard
Apr 16, 2015·American Journal of Respiratory and Critical Care Medicine·Michael J CutticaRavi Kalhan
May 6, 2016·Annals of the American Thoracic Society·David R Jacobs, Ravi Kalhan
Jul 28, 2016·Gene·Amr Hosny MalashRadwa Ahmed Shamma
Apr 7, 2018·American Journal of Respiratory and Critical Care Medicine·Paul A ReyfmanRavi Kalhan
Dec 19, 2018·Journal of the American Heart Association·Michael J CutticaRavi Kalhan

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Citations

Aug 26, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Yuanlong HuXianhai Chen
Nov 21, 2021·Molecular Genetics & Genomic Medicine·Ramya RamasubramanianBharat Thyagarajan

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Methods Mentioned

BETA
nuclear translocation
biopsies

Software Mentioned

SAS
nCounter analysis system
nCounter
CARDIA

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