Lung function at term in extremely preterm-born infants: a regional prospective cohort study

BMJ Open
Mariann Haavik BentsenThomas Halvorsen

Abstract

To compare lung function of extremely preterm (EP)-born infants with and without bronchopulmonary dysplasia (BPD) with that of healthy term-born infants, and to determine which perinatal characteristics were associated with lung function at term and how predictive these measurements were for later respiratory health in EP-born infants. Perinatal variables were recorded prospectively, and tidal breathing parameters were measured at term-equivalent age using electromagnetic inductance plethysmography. Respiratory morbidity was defined by hospital readmissions and/or treatment with asthma medications during the first year of life. Fifty-two EP-born infants (mean gestational age 261, range 226-276 weeks) and 45 term-born infants were included. There was evidence of significant airway obstruction, higher tidal volumes and increased minute ventilation in the EP-born infants with and without BPD, although generally more pronounced for those with BPD. Male gender, antenatal steroids and number of days on continuous positive airway pressure were associated with lung function outcomes at term. A prediction model incorporating two unrelated tidal breathing parameters, BPD, birth weight z-score and gender, predicted respiratory morbidity i...Continue Reading

Associated Clinical Trials

Jun 25, 2010·Trond Markestad

Citations

Feb 12, 2019·Expert Review of Anti-infective Therapy·Bosco Paes, Xavier Carbonell-Estrany
Jun 8, 2018·Breathe·Sarah J KotechaSailesh Kotecha
Oct 19, 2019·Experimental Physiology·Fiona B McDonaldKen D O'Halloran
Sep 29, 2019·The European Respiratory Journal·Liesbeth DuijtsMarielle W Pijnenburg
Jan 8, 2020·Pediatric Pulmonology·Christopher HarrisAnne Greenough
Mar 14, 2020·Pediatric Pulmonology·Danielle C GomesSilvana A Pereira
Aug 9, 2018·Annals of the American Thoracic Society·Clement L RenJames S Kemp
Aug 31, 2019·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·I-Ling Chen, Hsiu-Lin Chen
Nov 2, 2018·Annals of the American Thoracic Society·Thomas Halvorsen
Sep 9, 2020·Pediatric Pulmonology·Marie SautterMariann H L Bentsen
Dec 1, 2020·The Journal of Pediatrics·Anna LavizzariFabio Mosca
Feb 14, 2021·Pediatric Pulmonology·Eli RhoadsClement L Ren
Aug 19, 2021·Pediatric Pulmonology·Francesco BerettaMaria L Giannì
Oct 7, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maria L DiasFiona B McDonald

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Methods Mentioned

BETA
sedation
SGA
X-ray

Clinical Trials Mentioned

NCT01150396

Software Mentioned

VSP
MedCalc
SPSS
FloRight
VoluSense

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