Lung function decline and outcomes in an elderly population

Thorax
David M Mannino, K J Davis

Abstract

To determine the risk factors for and outcomes associated with the rapid decline in lung function in a cohort of elderly US adults. Data from 4923 adult participants aged 65 years and older at baseline in the Cardiovascular Health Study were analysed. Subjects were classified using a modification of the GOLD criteria for chronic obstructive pulmonary disease (COPD) and a "restricted" category (FEV1/FVC>or=70% and FVC<80% predicted) was added. Cox proportional hazard models were used to determine the risk of lung function decline over 4 years on subsequent mortality and COPD hospital admissions after adjusting for age, race, sex, smoking status, and other factors. Of the participants in the initial cohort, 3388 (68.8%) had spirometric tests at the year 4 visit. Participants with GOLD stages 3 or 4 COPD at baseline were less likely than normal subjects to have follow up spirometric tests (52.7% v 77.9%, p<0.01) and were more likely to be in the most rapidly declining quartile of FEV1 (28.2% v 21.3%, p<0.01) with an annual loss of FEV1 of at least 3.5%. Overall, being in the most rapidly declining quartile of FEV1 from baseline to year 4 was associated with an increased risk of admission to hospital for COPD (adjusted hazard ratio...Continue Reading

References

Oct 11, 1992·The American Review of Respiratory Disease·C B ShermanD W Dockery
Feb 1, 1991·Annals of Epidemiology·L P FriedA Newman
Mar 1, 1990·The American Review of Respiratory Disease·P LangeP Schnohr
Sep 1, 1989·The American Review of Respiratory Disease·N R Anthonisen
May 1, 1994·American Journal of Respiratory and Critical Care Medicine·W van PeltP H Quanjer
May 1, 1996·Annals of Epidemiology·C M BurchfielJ D Curb
Oct 8, 1999·Stroke; a Journal of Cerebral Circulation·D C SteffensG L Burke
May 17, 2000·Current Opinion in Pulmonary Medicine·J C Chen, D M Mannino
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·K A GriffithP L Enright
Feb 25, 2003·American Journal of Respiratory and Critical Care Medicine·Gordon L Snider
Oct 14, 2003·Chest·Peter M A CalverleyUNKNOWN IOSLDE Study Group
Dec 19, 2003·The European Respiratory Journal·G C DonaldsonJ A Wedzicha
Mar 5, 2004·The New England Journal of Medicine·Bartolome R CelliHoward J Cabral
Jan 28, 2006·American Journal of Respiratory and Critical Care Medicine·David M ManninoKourtney J Davis

❮ Previous
Next ❯

Citations

May 14, 2010·Rejuvenation Research·James W Larrick, Andrew Mendelsohn
Feb 28, 2008·Current Opinion in Pulmonary Medicine·Margit Pelkonen
Feb 28, 2008·Current Opinion in Pulmonary Medicine·Don D Sin, S F Paul Man
Apr 4, 2007·Postgraduate Medical Journal·Fotis SampsonasKostas Spiropoulos
Aug 4, 2007·American Journal of Respiratory and Critical Care Medicine·Stacey E AlexeeffJoel Schwartz
Apr 4, 2009·American Journal of Respiratory and Critical Care Medicine·Robab KohansalJoan B Soriano
Aug 1, 2013·Respiratory Research·Gavin C DonaldsonJadwiga A Wedzicha
Dec 7, 2013·BMC Surgery·Francesco TurràFabrizio Schonauer
Nov 16, 2013·BMC Medicine·Adam K H Usher, Robert A Stockley
Dec 16, 2010·BMC Medicine·Peter N Lee, John S Fry
Jun 12, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Marc Miravitlles, Antonio Anzueto
Jul 31, 2010·International Journal of Telemedicine and Applications·Michael StellefsonJ Don Chaney
May 17, 2014·Expert Review of Respiratory Medicine·Abebaw M Yohannes, Gindo Tampubolon
Feb 26, 2016·Respiratory Medicine·Maria C MirabelliStephanie J London
Nov 21, 2007·COPD·Adam L FriedlanderRussell P Bowler
Oct 31, 2008·COPD·Keiichiro AkamatsuMasakazu Ichinose
Feb 9, 2008·COPD·Andrew Bush
Apr 7, 2010·Chest·Jill A OharEugene R Bleecker
Nov 5, 2011·Chest·Claudio PedoneRaffaele Antonelli-Incalzi
Mar 10, 2011·Mathematical Biosciences·Bryan N BrownYoram Vodovotz
Sep 4, 2007·Lancet·David M Mannino, A Sonia Buist
Oct 2, 2009·Journal of the American Geriatrics Society·Simone ScarlataRaffaele Antonelli Incalzi
Sep 13, 2008·Journal of the American Academy of Nurse Practitioners·Kim K KueblerCynthia R Balkstra
Sep 3, 2011·Journal of the American Geriatrics Society·Mary E TinettiPeter Peduzzi
Oct 6, 2012·Journal of the American Geriatrics Society·Sandy S ChangMary E Tinetti
Mar 20, 2010·The Clinical Respiratory Journal·Sophie Charlotte HvidstenSverre Lehmann
May 30, 2006·Archives of Gerontology and Geriatrics·Eugenija ZuskinZijad Durakovic
Feb 4, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Shanshan LiGail M Williams
Aug 25, 2015·Pharmacology & Therapeutics·Ivan BernardoRoss Vlahos
Nov 14, 2013·Radiation Research·T V AzizovaE Bragin
Mar 21, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Johanna LepeuleJoel Schwartz
Jul 5, 2008·Respiratory Medicine·Simone ScarlataRaffaele Antonelli Incalzi
May 11, 2010·Respiratory Medicine·Jorien HanninkYvonne Heijdra
May 25, 2011·Korean Circulation Journal·Hwa Mu LeeNathan D Wong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.