Lung function discordance in monozygotic twins and associated differences in blood DNA methylation

Clinical Epigenetics
Anneli C S BolundTorben Sigsgaard

Abstract

Lung function is an important predictor of morbidity and mortality, with accelerated lung function decline reported to have immense consequences for the world's healthcare systems. The lung function decline across individual's lifetime is a consequence of age-related changes in lung anatomical structure and combination of various environmental factors; however, the exact molecular mechanisms contributing to this decline are not fully understood. DNA methylation is an epigenetic modification that changes across individual's lifetime, as well as allows for interplay between environmental and genetic factors. DNA methylation plays a crucial role in regulation of gene expression, with increasing evidence linking aberrant DNA methylation levels with a number of common human diseases. In this study, we investigated possible associations between genome-wide DNA methylation levels and lung function in 169 pairs of middle-aged monozygotic twins (86 male pairs: mean age (min-max) = 66 years (57-79); 83 female pairs: mean age (min-max) = 66 years (56-78)). The twins were collected from the Danish Twin Registry and were examined at baseline (1998-1999) and follow-up (2008-2011) visits. Using the twin design, we correlated intra-pair differ...Continue Reading

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Citations

Mar 28, 2018·American Journal of Respiratory and Critical Care Medicine·Dawn L DeMeo
Sep 24, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Dorthe Almind PedersenKaare Christensen
Jan 30, 2020·American Journal of Respiratory and Critical Care Medicine·Jarrett D MorrowDawn L DeMeo
Jun 21, 2020·Aging·Cuicui WangJoel Schwartz
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Jul 10, 2021·Frontiers in Neuroscience·Charlotte K BainomugisaDivya Mehta

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Methods Mentioned

BETA
methylation profiling
flow cytometry

Software Mentioned

EWAS
GitHub
FunNorm
MethylAid
WebGestalt )
R
GEne SeT AnaLysis Toolkit (
minfi

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