PMID: 7545431May 1, 1995Paper

Lung function impairment in long-term survivors of Hodgkin's disease

Annals of Oncology : Official Journal of the European Society for Medical Oncology
M B LundJ Boe

Abstract

Treatment of Hodgkin's disease (HD) involves radiation and chemotherapy, modalities known to cause lung injury. In Norway, between 1980 and 1988, 129 patients aged less than 50 years at the time of diagnosis, had curative treatment with thoracic radiation alone or combined-modality therapy for supradiaphragmatic HD. We have examined 116 (90%) of these patients by interview, chest X-ray and lung function tests, 5-13 years after treatment. Nearly 30% of the patients had dyspnoea on exertion and associated reductions in total lung capacity (TLC), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and gas transfer (TLCO) (p < 0.05). Radiographic evidence of no, slight or moderate fibrosis occurred in 32%, 54% and 14% of the patients, respectively. Moderate fibrosis was associated with reductions in FVC, FEV1 and TLCO (p < 0.05). Radiation plus chemotherapy containing bleomycin-anthracyclines (median cumulative bleomycin dose 120 mg) was associated with decreases in FVC and TLCO (p < 0.05). In the multivariate analysis, chemotherapy with bleomycin-anthracyclines was the only significant predictor for lung function impairment. More than five years after therapy, respiratory symptoms and reduction in lung functio...Continue Reading

Citations

Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J C TheuwsJ V Lebesque
Jul 27, 1999·Acta Oncologica·A F AbrahamsenS Kvaløy
Sep 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marianne J HjermstadJon H Loge
Feb 25, 1998·Medical and Pediatric Oncology·K NysomB Hesse
Jul 4, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H KnobelS Kaasa
Apr 13, 2006·Paediatric Drugs·Robert E GoldsbyArthur R Ablin
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph R CarverUNKNOWN ASCO Cancer Survivorship Expert Panel
May 2, 2003·European Journal of Nuclear Medicine and Molecular Imaging·K E Kogel, J W Sweetenham
Sep 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karyn A GoodmanJoachim Yahalom
Jun 21, 2013·Hematological Oncology·Tim Illidge
Jan 17, 2021·Journal of Cancer Survivorship : Research and Practice·Andrea C LoKaren Goddard
Jan 16, 1999·Pediatric Clinics of North America·M Grossi

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