Lung function in African infants: a pilot study

Pediatric Pulmonology
D M GrayHeather J Zar

Abstract

The burden of childhood respiratory illness is large in low and middle income countries (LMICs). Infant lung function (ILF) testing may provide useful information about lung growth and susceptibility to respiratory disease. However, ILF has not been widely available in LMICs settings where the greatest burden of childhood respiratory disease occurs. To implement and evaluate a pilot study of ILF testing in a semi-rural setting in South Africa. Infant lung function testing was established at a community hospital in South Africa. All measures were done in unsedated infants during sleep. Measurements, made with the infant quietly breathing through a face mask and bacterial filter, included tidal breathing (TBFVL), exhaled nitric oxide (eNO), and sulphur hexafluoride multiple breath washout (MBW) measures using an ultrasonic flow meter and chemoluminescent NO analyzer. Twenty infants, mean age of 7.7 (SD 2.9) weeks were tested; 8 (40%) were Black African and 12 (60%) were mixed race. Five (25%) infants were preterm. There were 19 (95%) successful TBFVL and NO tests and 18 (90%) successful MBW tests. The mean tidal volume was 30.5 ml (SD 5.9), respiratory rate 50.2 breaths per minute (SD 8.7), and eNO 10.4 ppb (SD 7.3). The mean MBW...Continue Reading

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Citations

Aug 19, 2015·Pediatric Pulmonology·Pinelopi AnagnostopoulouPhilipp Latzin
Jul 3, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Diane GrayHeather J Zar
Sep 12, 2015·Pediatric Pulmonology·Hendrik Stefan FischerGerd Schmalisch
Jun 16, 2015·Annals of the American Thoracic Society·Padmaja SubbaraoWayne Morgan
Apr 29, 2016·Pediatric Pulmonology·Richard AutenTerry L Noah
Apr 19, 2015·BMC Pulmonary Medicine·Payal H MandaliyaJoerg Mattes
Aug 11, 2016·American Journal of Respiratory and Critical Care Medicine·Diane M GrayHeather J Zar
Nov 11, 2016·Annals of the American Thoracic Society·Lauren WillemseDiane M Gray
Nov 20, 2016·Thorax·Diane GrayHeather J Zar
Jun 19, 2019·Pediatric Pulmonology·Anna ShawcrossAlex Horsley
Jan 18, 2020·The European Respiratory Journal·Anke HülsHeather J Zar
Feb 6, 2016·Physiological Measurement·Pinelopi AnagnostopoulouPhilipp Latzin
Apr 20, 2018·Pediatric Pulmonology·Andrew Bush
Jul 27, 2021·Clinical & Translational Immunology·Gabriela Martins Costa GomesAdam M Collison

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Methods Mentioned

BETA
sedation

Software Mentioned

Wbreath
STATA

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