Lung Function Trajectories in World Trade Center-Exposed New York City Firefighters Over 13 Years: The Roles of Smoking and Smoking Cessation

Chest
Thomas K AldrichDavid J Prezant

Abstract

World Trade Center (WTC)-exposed Fire Department of the City of New York firefighters lost, on average, 10% of lung function after September 11, 2011, and >10% developed new obstructive airways disease. There was little recovery (on average) over the first 6 years. Follow-up into the next decade allowed us to determine the longer-term exposure effects and the roles of cigarette smoking and cessation on lung function trajectories. We examined serial measurements of FEV1 from March 11, 2000, to September 10, 2014, among 10,641 WTC-exposed Fire Department of the City of New York firefighters with known smoking and body weight histories. The median number of FEV1 measurements during follow-up was 9; 15% of firefighters arrived at the WTC during the morning of September 11, 2001; and 65% never smoked. Firefighters arriving the morning of September 11, 2001 averaged lower lung function than did lesser exposed firefighters; this difference remained significant during most of follow-up (P < .05). Never smokers had significantly better lung function than current smokers; former smokers fell in between, depending upon their cessation date. Those arriving the morning of September 11, 2001 were more likely to have an FEV1 < lower limits of...Continue Reading

References

Nov 11, 1992·The American Review of Respiratory Disease·X XuB G Ferris
Feb 1, 1988·The American Review of Respiratory Disease·D W DockeryA Spiro
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·C M BurchfielA S Buist
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·P D ScanlonUNKNOWN Lung Health Study Research Group
Sep 13, 2002·The New England Journal of Medicine·David J PrezantKerry J Kelly
Jul 5, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Oct 20, 2005·Occupational and Environmental Medicine·M-L WangM D Atffield
Apr 29, 2006·American Journal of Respiratory and Critical Care Medicine·Gisela I BanauchDavid J Prezant
Apr 9, 2008·Respiratory Research·Bharat ThyagarajanO Dale Williams
Aug 12, 2009·American Journal of Industrial Medicine·Mei Lin WangEdward L Petsonk
Apr 9, 2010·The New England Journal of Medicine·Thomas K AldrichDavid J Prezant
Dec 16, 2010·BMC Medicine·Peter N Lee, John S Fry
Sep 9, 2011·Disaster Medicine and Public Health Preparedness·Jackie SooDavid J Prezant
Oct 4, 2011·American Journal of Industrial Medicine·Mayris P WebberDavid Prezant
Sep 22, 2012·Journal of Occupational and Environmental Medicine·Mengling LiuJoan Reibman

❮ Previous
Next ❯

Citations

Sep 2, 2016·American Journal of Industrial Medicine·Rachel Zeig-OwensMichael D Weiden
Nov 12, 2016·Chest·Thomas Aldrich
Jul 23, 2016·Chest·Thomas K AldrichDavid J Prezant
Apr 19, 2017·Annals of the American Thoracic Society·Eleanor M SummerhillUNKNOWN ATS Terrorism and Inhalational Disasters Section of the Environmental, Occupational, and Population Health Assembly
Sep 22, 2018·Current Opinion in Rheumatology·Laure GallayBaptiste Hervier
Jan 23, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Tom Tanjeko AjimeGhislaine Gayan-Ramirez
Sep 6, 2019·Current Allergy and Asthma Reports·Robert H WautersTaylor A Banks
May 16, 2019·International Journal of Environmental Research and Public Health·Charles LiuMichael D Weiden
Jan 18, 2018·Current Opinion in Allergy and Clinical Immunology·Anne E Wyman, Stella E Hines
May 1, 2019·International Journal of Environmental Research and Public Health·Sophia KwonAnna Nolan
Feb 10, 2017·Current Allergy and Asthma Reports·Krystal L ClevenDavid J Prezant
Oct 11, 2020·International Journal of Environmental Research and Public Health·Albeliz Santiago-ColónJohn Howard
Jul 22, 2021·American Journal of Industrial Medicine·Michael D WeidenDavid J Prezant
Jun 18, 2021·Journal of Occupational and Environmental Medicine·Elliot L GrahamDenise L Smith
Aug 21, 2021·American Journal of Industrial Medicine·Alexandra K MuellerRachel Zeig-Owens
Sep 3, 2021·American Journal of Respiratory and Critical Care Medicine·Sophia KwonAnna Nolan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.