Lung function trajectories throughout childhood in survivors of very preterm birth: a longitudinal cohort study

The Lancet Child & Adolescent Health
Shannon J SimpsonGraham L Hall

Abstract

Data on longitudinal respiratory follow-up after preterm birth in the surfactant era are scarce and of increasing importance, with concerns that preterm survivors are destined for early onset chronic obstructive airway disease. We aimed to comprehensively assess lung function longitudinally from early childhood to mid-childhood in very preterm children (≤32 weeks gestation), and to explore factors negatively impacting on lung function trajectories. Preterm children (with and without bronchopulmonary dysplasia) and healthy term children as controls were studied. All preterm participants were born at 32 weeks' gestation or earlier at King Edward Memorial Hospital, Perth, WA, Australia, between 1997 and 2003. Bronchopulmonary dysplasia was defined as at least 28 days of supplemental oxygen requirement as assessed at 36 weeks' post-menstrual age. Spirometry, oscillatory mechanics, gas exchange, lung volumes, and respiratory symptoms were assessed at three visits, two in early childhood (4-8 years) and one in mid-childhood (9-12 years). CT of the chest was done in preterm children in mid-childhood. Respiratory symptoms were documented via questionnaire at each visit. Data were analysed longitudinally using linear mixed models. 200 v...Continue Reading

Citations

Feb 12, 2019·Expert Review of Anti-infective Therapy·Bosco Paes, Xavier Carbonell-Estrany
Sep 29, 2019·The European Respiratory Journal·Liesbeth DuijtsMarielle W Pijnenburg
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Jun 9, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Nitin KapurDominic A Fitzgerald
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Mar 20, 2019·The European Respiratory Journal·Alvar AgustiUNKNOWN Current members of the CADSET Clinical Research Collaboration
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Mar 28, 2019·American Journal of Respiratory and Critical Care Medicine·Ingrid A Laing
Jul 9, 2020·Frontiers in Pediatrics·James T D GibbonsShannon J Simpson
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Dec 1, 2020·The Journal of Pediatrics·Anna LavizzariFabio Mosca
Aug 14, 2019·The Journal of Pediatrics·Shannon J SimpsonVictoria Reynolds
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