Lung humoral response to Pseudomonas species

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
R B Fick

Abstract

Immunoglobulin G (IgG) is quantitatively the predominent immunoglobulin protein in the distal airway of the human host. IgG enters the distal lung from circulating pools and plasma cells located largely in the interstitium. Although all four IgG subclasses are present in human lung secretions, only subclasses G3 and, to a lesser degree, G1 attach to pulmonary macrophage membrane receptors. IgG opsonic antibodies are essential for the optimal clearance of a very troubling pathogen. Pseudomonas aeruginosa. Nosocomial pneumonia caused by this gram-negative bacillus responds poorly to potent antimicrobial agents and is associated with a 70% mortality. To a great extent the morbidity and mortality resulting from nosocomial pneumonia caused by Pseudomonas spp. are attributable to ineffective humoral immune response to this bacterium. IgG2 antibodies in response to pseudomonal lipopolysaccharide are poorly opsonic in the macrophage system, and derepression of the potent pseudomonal elastase, an enzyme with broad substrate specificity, contributes to the disruption of other IgG antibodies.

References

Jan 1, 1988·The American Review of Respiratory Disease·A J HanceR G Crystal
Sep 1, 1987·Journal of Applied Physiology·R B FickG W Hunninghake
Jun 28, 1985·The American Journal of Medicine·T C Eickhoff
Jul 15, 1985·The American Journal of Medicine·A KarnadS L Berk
Jun 1, 1982·Infection and Immunity·D McChesneyC C Brinton

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Citations

Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·D TalonJ F Viel
Jan 1, 1993·Microbiology and Immunology·K AhmedK Matsumoto
Jun 1, 1991·Scandinavian Journal of Immunology·T A OutH M Jansen

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