PMID: 15381503DOI: 10.1165/rcmb.2004-0124trSep 24, 2004Paper
Lung inflammation as a therapeutic target in cystic fibrosis
American Journal of Respiratory Cell and Molecular Biology
David R KoehlerJim Hu
Abstract
Cystic fibrosis (CF) lung disease is characterized by chronic neutrophilic inflammation and infection. Effective management of airway inflammation could complement other therapies for the treatment of CF. Recent progress has been made in understanding the signaling pathways regulating inflammatory cytokines in the lung. Here we examine the mechanisms responsible for inflammation in the CF lung, and discuss potential therapeutic strategies targeting inflammation.
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