Lung insufflation capacity in neuromuscular disease

American Journal of Physical Medicine & Rehabilitation
John Robert BachEugene Komaroff

Abstract

To compare maximal passive lung insufflation capacity (LIC) with lung inflation by air stacking (to maximum insufflation capacity [MIC]) and with vital capacity (VC); to explore relationships between these variables that correlate with glottic function and cough peak flows (CPF); to demonstrate the effect of routine inflation therapy on LIC and MIC; and to determine the relative importance of lung inflation therapy as a function of disease severity. Case series of 282 consecutive neuromuscular disease (NMD) clinic patients 7 yrs and older with VC <70% of the predicted normal value. All cooperative patients meeting these criteria were prescribed thrice-daily air stacking and/or maximal passive lung insufflation to pressures of 40-80 cm H2O, and they underwent measurements of VC, MIC, LIC, and unassisted and assisted CPF on every visit. Means +/- standard deviations for VC, MIC, and LIC were 1131 +/- 744, 1712 +/- 926, and 2069 +/- 867 ml, respectively, and, for unassisted and assisted CPF, they were 2.5 +/- 2.0 and 4.3 +/- 2.2 liters/sec, respectively, with all differences statistically significant (P < 0.001). MIC minus VC correlated inversely with LIC minus MIC (P = 0.01) and, therefore, with glottic function. Both MIC and LIC...Continue Reading

Associated Clinical Trials

Nov 13, 2013·Uwe Mellies

References

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May 23, 2000·American Journal of Physical Medicine & Rehabilitation·S W Kang, J R Bach
Jul 14, 2000·Chest·S W Kang, J R Bach
May 23, 2002·American Journal of Physical Medicine & Rehabilitation·Elia Gomez-Merino, John R Bach
Aug 11, 2004·American Journal of Respiratory and Critical Care Medicine·Jonathan D FinderUNKNOWN American Thoracic Society
Nov 13, 2004·Chest·John Robert BachElaine Aufiero
Mar 15, 2005·Pediatric Pulmonology·Leanne M Gauld, Alison Boynton
Jan 24, 2006·American Journal of Physical Medicine & Rehabilitation·John R BachPaulo Abreu
May 13, 2006·Journal of Applied Physiology·Leigh M SeccombeChristine R Jenkins
Apr 7, 2007·American Journal of Physical Medicine & Rehabilitation·Malin Nygren-BonnierBrita Klefbeck
Apr 7, 2007·American Journal of Physical Medicine & Rehabilitation·John R Bach, George Tewfik
Apr 24, 2007·American Journal of Physical Medicine & Rehabilitation·John R BachEugene Komaroff
Aug 5, 1977·Science

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Citations

Apr 22, 2010·American Journal of Physical Medicine & Rehabilitation·John R Bach, Alice Hon
Apr 25, 2012·The Journal of Spinal Cord Medicine·John R Bach
Mar 20, 2014·Neurodegenerative Disease Management·Susana Pinto, Mamede de Carvalho
Feb 4, 2016·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·María V Herrero, J R Bach
Mar 17, 2012·Archives of Physical Medicine and Rehabilitation·Douglas A McKimCarole LeBlanc
Aug 21, 2013·Pediatric Pulmonology·H M JenkinsH Pasterkamp
Aug 5, 2009·Archives of Physical Medicine and Rehabilitation·Sang Chul LeeSang Ha Song
Mar 17, 2015·PM & R : the Journal of Injury, Function, and Rehabilitation·John R Bach, Selorm L Takyi
Nov 11, 2014·Annals of the American Thoracic Society·Uwe Mellies, Christof Goebel
Jul 17, 2013·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Erik J A WestermannMike J Kampelmacher
Dec 5, 2014·Chronic Respiratory Disease·Florian StehlingUwe Mellies
May 21, 2017·Archives of Physical Medicine and Rehabilitation·Antonio SarmentoArmele Dornelas de Andrade
Oct 4, 2017·Annals of Rehabilitation Medicine·John R Bach
Oct 27, 2011·Yonsei Medical Journal·Dong Hyun KimHye Ree Lee
Nov 9, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Nicole SheersDavid J Berlowitz
Jan 5, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Bart VrijsenBertien Buyse
Jan 18, 2020·Pulmonary Medicine·Athanasios VoulgarisPaschalis Steiropoulos
Nov 21, 2014·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Tanyse Bahia Carvalho MarquesUmbertina Conti Reed
Oct 25, 2020·Pediatric Pulmonology·Grace R PaulRichard Shell
Sep 4, 2020·Archives of Physical Medicine and Rehabilitation·Rachel O'SullivanRebecca Hemming
Jul 31, 2021·BMJ Open Respiratory Research·Phoebe E NaughtonSherri L Katz

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