PMID: 9192943Jun 1, 1997Paper

Lung involvement in the multisystem syndrome CHARGE association

The European Respiratory Journal
R SporikC Wallis

Abstract

The CHARGE association is a multisystem syndrome, with a wide range of phenotypic expression, causing mortality, especially in childhood. We performed a hospital audit, in order to quantify the pulmonary implications, in 28 boys and 19 girls aged 0.02-23 yrs, with a definite diagnosis of CHARGE. A review of the records of these children with CHARGE association revealed that aspiration was common during infancy, as a result of inco-ordination of swallowing and gastro-oesophageal reflux. Aspiration was suspected in 22 of the 47 cases (47%), recurrent chest infections occurred in 22 cases (47%), and lung involvement contributed to 7 out of 17 deaths (41%). We conclude that respiratory morbidity and mortality is common in CHARGE, and decreases with age. Early diagnosis and treatment affords the best prognosis.

Citations

May 14, 2005·International Journal of Pediatric Otorhinolaryngology·David R WhiteMichael J Rutter
Jun 30, 2004·Paediatric Respiratory Reviews·Robert Dinwiddie
Nov 14, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Peter HsuSam Mehr
Mar 16, 2012·American Journal of Medical Genetics. Part a·Kim D BlakeGerard Corsten
Feb 20, 2014·Journal of Paediatrics and Child Health·Peter HsuSam Mehr
May 8, 2010·Clinical Genetics·J E H BergmanC M A van Ravenswaaij-Arts
Oct 31, 2017·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Kim D Blake, Alexandra S Hudson

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