PMID: 6408334Apr 1, 1983Paper

Lung lipid synthesis from acetoacetate and glucose in developing rats in vitro

Lipids
P M Sheehan, Y Y Yeh

Abstract

Acetoacetate (AcAc) and glucose were compared as energy sources and as precursors for lipid synthesis in the lungs of developing rats. Minced lung tissue was incubated with [3-14C]AcAc or [U-14C]glucose and the oxidation of each substrate to CO2 or its incorporation into tissue lipids was quantified. The highest rates of oxidation were obtained during the first 5 days for AcAc and the first 2 days of life for glucose and oxidation of AcAc was 3-4 times greater than that of glucose at all ages. Throughout postnatal development, the rates of nonsaponifiable lipid, fatty acid and hence total lipid (chloroform/methanol extractable) synthesis from AcAc were 2-3 times those of glucose. The highest rates of total lipid synthesis from AcAc and glucose were observed at birth. Glucose was utilized for glyceride-glycerol synthesis at a higher rate than AcAc. Similar patterns of incorporation of AcAc and glucose into various lipid classes were noted. Of the total lipids synthesized from AcAc and glucose, respectively, phospholipid plus monoglyceride accounted for 64% and 77%, triglyceride 13% and 13%, diglyceride plus cholesterol 11% and 4%, fatty acids 9% and 4%, and cholesteryl esters 3% and 1%. AT birth, the specific activities of all l...Continue Reading

References

Sep 28, 1977·Biochimica Et Biophysica Acta·D W SeccombeF Possmayer
Mar 1, 1976·Pediatric Research·Y Y Yeh, P Zee
Mar 1, 1972·Lipids·M C Wang, H C Meng
Jan 1, 1971·Biology of the Neonate·L C Mims, P Zee
Apr 15, 1982·Biochimica Et Biophysica Acta·W M ManiscalcoA B Parkhurst
Apr 1, 1980·Pediatric Research·J B WarshawM B Ranis
Jan 1, 1982·The International Journal of Biochemistry·Y Y Yeh
Jan 1, 1981·Lung·R H PerelmanP M Farrell
Sep 24, 1981·Biochimica Et Biophysica Acta·K F Buechler, R A Rhoades
Aug 11, 1980·Biochimica Et Biophysica Acta·K F Buechler, R A Rhoades
Oct 1, 1964·The Journal of Nutrition·H A DymszaS A Miller
Jan 1, 1945·The Biochemical Journal·H A Krebs, L V Eggleston

❮ Previous
Next ❯

Citations

Aug 14, 1986·Biochimica Et Biophysica Acta·C E PattersonR A Rhoades
Jan 1, 1988·Experimental Lung Research·M J EngleM Dooley
Jan 1, 1986·Experimental Lung Research·C E PattersonR A Rhoades
Sep 3, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher J PynnWolfgang Bernhard
Sep 12, 1986·Biochimica Et Biophysica Acta·B D Uhal, W J Longmore

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.