Lung Macrophage Phenotypes and Functional Responses: Role in the Pathogenesis of COPD

International Journal of Molecular Sciences
Kei Yamasaki, Stephan F van Eeden

Abstract

Lung macrophages (LMs) are essential immune effector cells that are pivotal in both innate and adaptive immune responses to inhaled foreign matter. They either reside within the airways and lung tissues (from early life) or are derived from blood monocytes. Similar to macrophages in other organs and tissues, LMs have natural plasticity and can change phenotype and function depending largely on the microenvironment they reside in. Phenotype changes in lung tissue macrophages have been implicated in chronic inflammatory responses and disease progression of various chronic lung diseases, including Chronic Obstructive Pulmonary Disease (COPD). LMs have a wide variety of functional properties that include phagocytosis (inorganic particulate matter and organic particles, such as viruses/bacteria/fungi), the processing of phagocytosed material, and the production of signaling mediators. Functioning as janitors of the airways, they also play a key role in removing dead and dying cells, as well as cell debris (efferocytic functions). We herein review changes in LM phenotypes during chronic lung disease, focusing on COPD, as well as changes in their functional properties as a result of such shifts. Targeting molecular pathways involved i...Continue Reading

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Aug 25, 2020·PloS One·Jacquelyn GerhartMindy George-Weinstein
Aug 15, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chang-Jiang GuoAndrew J Gow
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Aug 26, 2021·Respiratory Research·Spela KokeljAnna-Carin Olin
Sep 4, 2019·Respiration; International Review of Thoracic Diseases·Stephan F van Eeden, James C Hogg

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Methods Mentioned

BETA
Bronchoalveolar Lavage

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