Lung management protocols increase the incidence of lung procurement and organ transplantation: A meta-analysis

Physiotherapy Theory and Practice
Cassandra RaiosJennifer L Keating

Abstract

Improved donor management, including respiratory physiotherapy, may optimize donor suitability and increase successful lung procurement. This review aimed to determine the efficacy of lung management protocols on the incidence of successful lung procurement and transplantation. Searches were completed in MEDLINE, CINAHL, EMBASE, PubMed, PEDRO, and Cochrane Registry of Controlled Clinical Trials, from database inception to March 2018. Randomized controlled trials and observational studies, with a control or comparison group, of humans, published in English, in peer-reviewed journals were included. Any respiratory management was eligible. Two investigators assessed eligibility and study quality. Meta-analysis and narrative analysis were completed. Ten of 430 articles identified were eligible for inclusion. Implementation of protocols in potential donors increased the incidence of lung procurement, odds ratio (OR), 95% CI: 3.42 (2.48, 4.71) and transplantation procedures OR 2.56 (1.41, 4.62) compared to control groups. Recipient survival was significantly higher, in favor of lung management protocols compared to control groups at 30 days (OR 2.37 (1.14, 4.95)) and 1 year (OR 1.82 (1.02, 3.27)). Pooling of randomized controlled tri...Continue Reading

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Citations

Oct 17, 2019·Seminars in Cardiothoracic and Vascular Anesthesia·Barbara J Wilkey, Benjamin A Abrams
Dec 16, 2018·Medizinische Klinik, Intensivmedizin und Notfallmedizin·S-O Kuhn, K Hahnenkamp
May 9, 2019·Seminars in Cardiothoracic and Vascular Anesthesia·Justin N TawilMichael L Boisen
Sep 17, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·James Neuberger, Chris Callaghan
Aug 15, 2021·Transplantation Proceedings·Lauren Rachel O'Connor

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