Lung Microvascular Niche, Repair, and Engineering

Frontiers in Bioengineering and Biotechnology
Tomoshi TsuchiyaTakeshi Nagayasu

Abstract

Biomaterials have been used for a long time in the field of medicine. Since the success of "tissue engineering" pioneered by Langer and Vacanti in 1993, tissue engineering studies have advanced from simple tissue generation to whole organ generation with three-dimensional reconstruction. Decellularized scaffolds have been widely used in the field of reconstructive surgery because the tissues used to generate decellularized scaffolds can be easily harvested from animals or humans. When a patient's own cells can be seeded onto decellularized biomaterials, theoretically this will create immunocompatible organs generated from allo- or xeno-organs. The most important aspect of lung tissue engineering is that the delicate three-dimensional structure of the organ is maintained during the tissue engineering process. Therefore, organ decellularization has special advantages for lung tissue engineering where it is essential to maintain the extremely thin basement membrane in the alveoli. Since 2010, there have been many methodological developments in the decellularization and recellularization of lung scaffolds, which includes improvements in the decellularization protocols and the selection and preparation of seeding cells. However, ear...Continue Reading

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Citations

Mar 6, 2021·Biomaterials Science·Himadri Shekhar RoyDeepa Ghosh
Apr 1, 2021·Journal of Biomaterials Science. Polymer Edition·Md Mohosin Rana
Aug 7, 2021·Frontiers in Bioengineering and Biotechnology·Shuai ChenVahid Serpooshan
Aug 26, 2021·Regenerative Medicine·Seyed Hossein MahfouziGhassem Amoabediny

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Methods Mentioned

BETA
biopsies
chip
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