PMID: 8946582Oct 1, 1996Paper

Lung morphometric changes after exposure to hypobaria and/or hypoxia and undernutrition

Respiration Physiology
H S Sekhon, W M Thurlbeck

Abstract

Lung morphometry was studied in rats between 4 and 7 weeks of age. The animals were divided into 5 groups: general controls (fed ad libitum), hypobaric normoxic, normobaric hypoxic, hypobaric hypoxic, and weight-matched controls (weight matched to the hypobaric hypoxic group). In both hypobaric and normobaric hypoxia, lung volume, alveolar surface area and total alveolar number increased compared to weight-matched controls. In normobaric hypoxia, mean linear intercept, mean chord length of alveoli increased and number of alveoli/unit volume decreased compared to weight-matched animals. In hypobaric hypoxia, only mean chord length increased. Dysanaptic index decreased in both. In hypobaric normoxia, alveolar size and lung volume diminished compared to general controls. Lung growth was impaired in weight-matched controls without affecting airspace dimensions. Hypobaric and normobaric hypoxia increase lung growth overcoming nutritional effects but is dysanaptic. Lung growth in hypobaric hypoxia is mainly determined by low oxygen but low pressure may also produce subtle structural alterations.

References

May 1, 1989·Respiration Physiology·E E Faridy, W Z Yang
Aug 1, 1988·Respiration Physiology·E E FaridyJ A Thliveris
Oct 1, 1971·Respiration Physiology·D Bartlett, J E Remmers
Apr 1, 1984·Forensic Science International : Synergy·H H HoppeP J Lincoln
May 1, 1984·The American Journal of Anatomy·M KawakamiW M Thurlbeck
Nov 1, 1980·Respiration Physiology·A J Lechner, N Banchero
Apr 1, 1995·Clinical and Experimental Pharmacology & Physiology·S B Hooper, R Harding
Sep 1, 1996·Respiration Physiology·H S Sekhon, W M Thurlbeck

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Citations

Apr 2, 2003·Seminars in Neonatology : SN·Sheila G Haworth, Alison A Hislop
Sep 28, 2005·High Altitude Medicine & Biology·Chandrashekhar V Apte, K Sudhakar Rao
Oct 17, 2009·Journal of Applied Physiology·Priya RavikumarConnie C W Hsia
Jul 29, 2004·American Journal of Respiratory and Critical Care Medicine·UNKNOWN ad hoc Statement Committee, American Thoracic Society
Apr 7, 2007·Pediatric Research·Namasivayam AmbalavananYiu-Fai Chen
Sep 27, 2015·American Journal of Physical Anthropology·Charles A WeitzChen-Ting Chin
Mar 3, 2015·Physiological and Biochemical Zoology : PBZ·Warren W Burggren, Casey A Mueller
Dec 24, 2014·Respiratory Physiology & Neurobiology·Priya RavikumarConnie C W Hsia
Apr 26, 2005·Respiratory Physiology & Neurobiology·Connie C W HsiaDennis J Bellotto
Oct 12, 2004·Journal of Applied Physiology·Connie C W Hsia
Apr 28, 2019·The Journal of Experimental Biology·Lara do Amaral-SilvaKênia Cardoso Bícego
May 4, 2012·American Journal of Physical Anthropology·Melisa KiyamuTom D Brutsaert
Mar 17, 2007·Journal of Applied Physiology·Cuneyt YilmazConnie C W Hsia
Aug 17, 2002·Journal of Applied Physiology·Alfin G VicencioGabriel G Haddad
Aug 4, 2004·Respiratory Physiology & Neurobiology·Jacopo P Mortola

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