Lung MRI with hyperpolarised gases: current & future clinical perspectives.

The British Journal of Radiology
Neil J StewartJim M Wild

Abstract

The use of pulmonary MRI in a clinical setting has historically been limited. Whilst CT remains the gold-standard for structural lung imaging in many clinical indications, technical developments in ultrashort and zero echo time MRI techniques are beginning to help realise non-ionising structural imaging in certain lung disorders. In this invited review, we discuss a complementary technique - hyperpolarised (HP) gas MRI with inhaled 3He and 129Xe - a method for functional and microstructural imaging of the lung that has great potential as a clinical tool for early detection and improved understanding of pathophysiology in many lung diseases. HP gas MRI now has the potential to make an impact on clinical management by enabling safe, sensitive monitoring of disease progression and response to therapy. With reference to the significant evidence base gathered over the last two decades, we review HP gas MRI studies in patients with a range of pulmonary disorders, including COPD/emphysema, asthma, cystic fibrosis, and interstitial lung disease. We provide several examples of our experience in Sheffield of using these techniques in a diagnostic clinical setting in challenging adult and paediatric lung diseases.

References

Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·R UppaluriG McLennan
Sep 30, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·X J ChenG A Johnson
Aug 5, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B T SaamM S Conradi
Mar 10, 2001·Journal of Magnetic Resonance Imaging : JMRI·T A AltesJ R Brookeman
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dmitriy A YablonskiyMark S Conradi
May 19, 2005·European Journal of Radiology·Andrew J SwiftEdwin J R Van Beek
Oct 29, 2005·Academic Radiology·Sean B FainJohn Owers-Bradley
Jan 28, 2006·American Journal of Respiratory and Critical Care Medicine·Barnaby WatersMike Silverman
Oct 24, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jason C WoodsJames C Hogg
Nov 11, 2006·Journal of Magnetic Resonance Imaging : JMRI·Talissa A AltesJohn P Mugler
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Klaus F RabeUNKNOWN Global Initiative for Chronic Obstructive Lung Disease
May 16, 2008·American Journal of Respiratory and Critical Care Medicine·Pranab HaldarRuth H Green
Jun 23, 2009·The European Respiratory Journal·E J R van BeekH-U Kauczor
Jul 25, 2009·Journal of Magnetic Resonance Imaging : JMRI·Martin H DeppeJim M Wild
Aug 8, 2009·Journal of Applied Physiology·Dmitriy A YablonskiyMark S Conradi
Oct 27, 2009·Journal of Magnetic Resonance Imaging : JMRI·Neil WoodhouseChristopher J Taylor
Mar 18, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S Sivaram KaushikBastiaan Driehuys
Jun 4, 2011·The Journal of Allergy and Clinical Immunology·Mario CastroUNKNOWN National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Nov 16, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J Parra-RoblesJ M Wild
Feb 2, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiaojun XuJim M Wild
Aug 15, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Stephen CostellaGrace Parraga
Dec 19, 2012·The Journal of Allergy and Clinical Immunology·Robert V CadmanSean B Fain
Apr 9, 2013·The European Respiratory Journal·Fabien MaldonadoJay H Ryu

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Citations

Sep 4, 2021·ERJ Open Research·Stephen MilneDon D Sin

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