Lung natural killer cells play a major counter-regulatory role in pulmonary vascular hyperpermeability after myocardial infarction

Circulation Research
Xiaoxiang YanMotoaki Sano

Abstract

Natural killer (NK) cells are lymphocytes of the innate immune system that play specialized and niche-specific roles in distinct organs. We investigated the possible function of NK cells in the pathogenesis of congestive heart failure after myocardial infarction. Depletion of NK cells from mice had little effect on cytokine expression (tumor necrosis factor-α, interleukin [IL]-6, and IL-1β), neutrophil and macrophage infiltration into infarcted myocardium, or left ventricular remodeling after myocardial infarction. However, these mice exhibited severe respiratory distress associated with protein-rich, high-permeability alveolar edema accompanied by neutrophil infiltration. In addition, there were 20-fold more NK cells in the mouse lungs than in heart, and these cells were accumulated around the vasculature. CD107a-positive and interferon-γ-positive cell populations were unchanged, whereas IL-10-positive populations increased. Adoptive transfer of NK cells from wild-type mice, but not from IL-10 knockout mice, into the NK cell-depleted mice rescued the respiratory phenotype. IL-1β-mediated dextran leakage from a lung endothelial cell monolayer was also blocked by coculture with NK cells from wild-type mice but not from IL-10 kno...Continue Reading

References

Nov 1, 1987·Journal of Applied Physiology·C M DoerschukJ C Hogg
Aug 17, 1999·The Journal of Clinical Investigation·W M KueblerJ Bhattacharya
Jul 19, 2000·Infection and Immunity·D F MorrisonM P Murtaugh
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D C CaraP Kubes
Feb 27, 2007·The American Journal of Pathology·Machteld J van AmerongenMarja J A van Luyn
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Thierry WalzerEric Vivier
Jun 5, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sean C GlasgowWilliam C Chapman
Apr 11, 2008·Genes and Immunity·L R GrantJ H Bream
Apr 22, 2008·Nature Immunology·Eric VivierSophie Ugolini
Dec 23, 2008·American Journal of Respiratory Cell and Molecular Biology·Lei SunThomas P Shanley
Feb 24, 2009·Blood·Laura ChiossoneThierry Walzer
Sep 24, 2011·Nature Reviews. Immunology·Fu-Dong ShiLuc Van Kaer
Dec 23, 2011·Basic Research in Cardiology·Ting-Ting TangXiang Cheng
Jan 11, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fredrik B ThorénAlessandro Moretta
Jul 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jihye LeeMasaaki Murakami
Sep 29, 2012·Science Translational Medicine·Paul C BlaineyStephen R Quake
Jan 12, 2013·Science·Filip K Swirski, Matthias Nahrendorf
Jan 15, 2013·Journal of the American Heart Association·Xiaoxiang YanMotoaki Sano
Feb 22, 2013·The Journal of Clinical Investigation·Hong ZhangHana Algül
May 7, 2013·Journal of Molecular and Cellular Cardiology·Xiaoxiang YanMotoaki Sano

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Citations

Sep 21, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Matthew T RätsepMark L Ormiston
Jul 31, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Homare ItoMasafumi Takahashi
Aug 16, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Orhan RasidJean-Marc Cavaillon
Jul 24, 2020·Cell and Tissue Research·Gurpreet Kaur Aulakh
Jan 27, 2020·Biochemical and Biophysical Research Communications·Kaoru YamashitaMotoaki Sano
Apr 14, 2020·Current Pharmaceutical Design·Konstantinos MourouzisDimitris Tousoulis

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