Lung nodule detection by microdose CT versus chest radiography (standard and dual-energy subtracted)

AJR. American Journal of Roentgenology
Lukas EbnerAndreas Christe

Abstract

The purpose of this study was to investigate the feasibility of microdose CT using a comparable dose as for conventional chest radiographs in two planes including dual-energy subtraction for lung nodule assessment. We investigated 65 chest phantoms with 141 lung nodules, using an anthropomorphic chest phantom with artificial lung nodules. Microdose CT parameters were 80 kV and 6 mAs, with pitch of 2.2. Iterative reconstruction algorithms and an integrated circuit detector system (Stellar, Siemens Healthcare) were applied for maximum dose reduction. Maximum intensity projections (MIPs) were reconstructed. Chest radiographs were acquired in two projections with bone suppression. Four blinded radiologists interpreted the images in random order. A soft-tissue CT kernel (I30f) delivered better sensitivities in a pilot study than a hard kernel (I70f), with respective mean (SD) sensitivities of 91.1%±2.2% versus 85.6%±5.6% (p=0.041). Nodule size was measured accurately for all kernels. Mean clustered nodule sensitivity with chest radiography was 45.7%±8.1% (with bone suppression, 46.1%±8%; p=0.94); for microdose CT, nodule sensitivity was 83.6%±9% without MIP (with additional MIP, 92.5%±6%; p<10(-3)). Individual sensitivities of micro...Continue Reading

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Dec 19, 2013·World Journal of Radiology·Andreas ChristeLukas Ebner

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Citations

Oct 21, 2016·The British Journal of Radiology·Robin Alexander KluthkeJohannes Kirchner
Nov 24, 2016·Acta Radiologica·Verena C ObmannEnno Stranzinger
Nov 22, 2019·JAMA Oncology·Sundeep AgrawalAndrea B Apolo
Jul 8, 2021·AJR. American Journal of Roentgenology·Samjhana ThapaliyaAndrew T Trout

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