Lung phagocyte bactericidal function in strains of mice resistant and susceptible to Pseudomonas aeruginosa.

Infection and Immunity
C MorissetteF Gervais

Abstract

The host response to Pseudomonas aeruginosa lung infection varies among inbred mouse strains. Mice of the BALB/c strain are resistant to P. aeruginosa lung infection, whereas mice of the DBA/2 strain are susceptible. This phenotypic variation correlates with a difference in the magnitude of the inflammatory response induced early following infection. In order to determine whether the ability of lung phagocytic cells to kill P. aeruginosa plays a role in the host response to the infection, we measured the in vitro bactericidal activity of resident and inflammatory alveolar and interstitial macrophages, using a temperature-sensitive mutant of P. aeruginosa. Lung macrophages obtained from resistant and susceptible animals displayed similar bactericidal activities, suggesting that the ability of phagocytes to kill P. aeruginosa does not play a crucial role in the outcome of infection. The bactericidal activity of lung phagocytes was also assessed in vivo following endobronchial infection with the temperature-sensitive mutant of P. aeruginosa. Resistant mice showed a rapid influx of polymorphonuclear leukocytes (PMNs) to the bronchoalveolar space which was shortly followed by an efficient clearance of the bacteria. Susceptible mice ...Continue Reading

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Citations

Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·N ShimeJ P Wiener-Kronish
Apr 27, 2013·Pathogens and Disease·Shaan L Gellatly, Robert E W Hancock
Feb 14, 2006·American Journal of Respiratory Cell and Molecular Biology·Megan N BallingerBethany B Moore
Jun 28, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Nicola Ivan LoréAlessandra Bragonzi
Apr 24, 2020·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Jimyeong HaKyoung-Hee Choi
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Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z C ChroneosJ A Whitsett
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Aug 1, 2007·Expert Review of Respiratory Medicine·Patricia J Dubin, Jay K Kolls
Aug 21, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Bryan J WilliamsTimothy S Blackwell
Nov 22, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaoliang LiangSule Çataltepe
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·M TamM M Stevenson
Mar 2, 2006·Ocular Immunology and Inflammation·Sharon A McClellanLinda D Hazlett
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Aug 16, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·B J McMorranB J Wainwright

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