Lung protective ventilation in patients undergoing major surgery: a systematic review incorporating a Bayesian approach

BMJ Open
Zhongheng ZhangChina Critical Care Clinical Trials Group (CCCCTG)

Abstract

Protective ventilation (PV) has been validated in patients with acute respiratory distress syndrome. However, the effect of PV in patients undergoing major surgery is controversial. The study aimed to explore the beneficial effect of PV on patients undergoing a major operation by systematic review and meta-analysis. Various levels of medical centres. Patients undergoing general anaesthesia. PV with low tidal volume. Study end points included acute lung injury (ALI), pneumonia, atelectasis, mortality, length of stay (LOS) in intensive care unit (ICU) and hospital. Databases including PubMed, Scopus, EBSCO and EMBASE were searched from inception to May 2015. Search strategies consisted of terms related to PV and anaesthesia. We reported OR for binary outcomes including ALI, mortality, pneumonia, atelectasis and other adverse outcomes. Weighted mean difference was reported for continuous outcomes such as LOS in the ICU and hospital, pH value, partial pressure of carbon dioxide, oxygenation and duration of mechanical ventilation (MV). A total of 22 citations were included in the systematic review and meta-analysis. PV had protective effect against the development of ALI as compared with the control group, with an OR of 0.41 (95% CI...Continue Reading

References

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Jan 11, 2013·Critical Care : the Official Journal of the Critical Care Forum·Zhongheng ZhangHongying Ni
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May 2, 2013·American Journal of Respiratory and Critical Care Medicine·Andrés EstebanAntonio Anzueto
Aug 2, 2013·The New England Journal of Medicine·Emmanuel FutierUNKNOWN IMPROVE Study Group
Dec 12, 2013·British Journal of Hospital Medicine·Vasileios A Zochios, Jonathan Wilkinson
Mar 19, 2014·BMJ Open·Zhongheng ZhangUNKNOWN China Critical Care Clinical Trials Group (CCCCTG)
May 16, 2015·Anesthesiology·Ary Serpa NetoUNKNOWN PROVE Network Investigators
Dec 15, 2015·Anesthesiology·Andreas GüldnerMarcelo Gama de Abreu

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Citations

Jan 28, 2017·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Zhongheng ZhangHongying Ni

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