PMID: 8419893Jan 1, 1993

Lung recoil and the determination of airflow limitation in cystic fibrosis and asthma

Pediatric Pulmonology
A ZapletalA L Coates

Abstract

A reduction of lung recoil pressure could aggravate any airflow limitation that might be present in patients with cystic fibrosis (CF) or asthma. In a group of 22 children and young adults (8 with cystic fibrosis, 8 with asymptomatic asthma, and 6 healthy controls) aged 8-24 years, lung recoil pressure (Pst) at 100%, 90%, and 60% of TLC and static lung compliance (Cst) were measured using an esophageal balloon. The indices of airflow limitation, including maximal expiratory flow at 25% VC (Vmax25), forced expiratory volume in 1 second (FEV1), and specific airway conductance (sGaw), were also measured. In all patients, Vmax25 was reduced, the airway obstruction being more pronounced in patients with CF. Pst was reduced in CF and asthma, again more in the patients with CF. Cst was normal in both groups because the pressure volume curve was shifted up and to the left. There were significant correlations between Pst at 60%, 90%, and 100% of TLC and both Vmax25 and FEV1 (P < 0.01). sGaw correlated with Pst90 and Pst60 (r = 0.47 and 0.53, respectively; P < 0.05 for both). No correlation was found between Cst and Pst at any lung volume. No correlations were observed between Cst and Vmax25, FEV1, or sGaw. These results suggest that los...Continue Reading

References

Apr 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·A De TroyerM Paiva
Jun 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·A L MansellH Levison
Sep 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S V Dawson, E A Elliott
Jun 1, 1976·Journal of Applied Physiology·A ZapletalM Samanek
Jan 1, 1976·Respiration; International Review of Thoracic Diseases·H von der HardtH Hellweg
May 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S T Holgate
Jun 1, 1989·The American Review of Respiratory Disease·D H EidelmanM G Cosio
Feb 1, 1988·The American Review of Respiratory Disease·K J DesmondA L Coates
Mar 1, 1987·Journal of Applied Physiology·D J DingP T Macklem
Jan 1, 1967·Journal of Applied Physiology·J MEADJ B Little
Nov 1, 1984·Pediatric Research·R Kraemer, F Geubelle
Mar 1, 1964·Journal of Applied Physiology·J Milic-EmiliE M GLAUSER

Citations

Feb 26, 2004·Paediatric Respiratory Reviews·A L Coates
May 1, 1995·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·D A BrandesP S Casamassimo
Aug 12, 1998·American Journal of Respiratory and Critical Care Medicine·I DurieuY Pacheco
Apr 28, 2012·American Journal of Respiratory and Critical Care Medicine·Daphna VilozniOri Efrati
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·Nicholas HartBrigitte Fauroux
Jan 19, 2010·Pediatric Pulmonology·Harm A W M TiddensPeter D Paré
Mar 13, 2002·Chest·Klaus Wassermann
Feb 5, 2003·Pediatric Pulmonology·Erich TauberThomas Frischer
Dec 10, 2015·The Cochrane Database of Systematic Reviews·Katharine ChengRosalind L Smyth
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Oct 1, 1996·Archives of Disease in Childhood·I M Balfour-LynnRobert Dinwiddie
Aug 1, 1994·Thorax·R K Brown, F J Kelly

Related Concepts

Airway Resistance
Asthma
Pulmonary Cystic Fibrosis
Lung
Lung Compliance
Respiratory Function Tests
Rietveld Refinement

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