PMID: 11923555Mar 30, 2002Paper

Lung restricted T cell receptor AV2S3+ CD4+ T cell expansions in sarcoidosis patients with a shared HLA-DRbeta chain conformation

Thorax
Johan GrunewaldOlle Olerup

Abstract

Sarcoidosis is a systemic disease of unknown aetiology frequently affecting the lungs. CD4+ T cells, in particular, accumulate in the lungs, implicating them in the pathogenesis of the disease. T cell receptor (TCR) variable (V) gene expression on bronchoalveolar lavage (BAL) fluid T cells and the HLA DR alleles of 121 Scandinavian patients with sarcoidosis was determined. As expected from our previous results, almost every DRB1*0301 (i.e. DR17) positive patient (67/69) had significantly increased numbers of AV2S3+ CD4+ T cells in the BAL fluid but normal levels in peripheral blood (that is, lung restricted expansions) compared with only six of 52 DRB1*0301 negative patients. Detailed genotypic HLA analysis showed that these six DRB1*0301 negative patients with lung restricted AV2S3+ T cell expansions had another HLA allele in common-the HLA-DRB3*0101 allele (also called DR52a)-which was not found in any other DRB1*0301 negative patient. A new group of sarcoidosis patients was therefore identified, characterised by a strict correlation between a distinct HLA allele and lung accumulated T cells expressing a particular TCR V segment. Furthermore, the HLA-DRB1*0301 and HLA-DRB3*0101 encoded molecules showed similarities, with iden...Continue Reading

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Citations

May 4, 2012·Journal of Clinical Immunology·Kyra A Oswald-RichterWonder P Drake
Aug 9, 2003·Current Opinion in Pulmonary Medicine·Paola Rottoli, Elena Bargagli
Aug 24, 2006·Current Opinion in Pulmonary Medicine·Wonder Puryear Drake, Lee S Newman
Jul 31, 2008·Current Opinion in Pulmonary Medicine·Johan Grunewald
Jan 5, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Marc A Judson
Dec 6, 2003·American Journal of Respiratory and Critical Care Medicine·Johan GrunewaldOlle Olerup
Nov 3, 2007·The Journal of Clinical Investigation·Jan WahlströmJohan Grunewald
Nov 26, 2010·Respiratory Research·Kyra A Oswald-RichterWonder Drake
Aug 9, 2007·Proceedings of the American Thoracic Society·Johan Grunewald, Anders Eklund
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Nov 1, 2006·Expert Review of Clinical Immunology·Johan GrunewaldJan Wahlström
Dec 14, 2011·Expert Review of Clinical Immunology·Johan Grunewald
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