Lung Sound Analysis and the Respiratory Cycle Dependence of Impulse Oscillometry in Asthma Patients

Internal Medicine
Terufumi ShimodaTomoaki Iwanaga

Abstract

Objective A lung sound analysis (LSA) is useful for detecting airway inflammation and obstruction in patients with asthma. To elucidate the mechanism of LSA, we investigated the relationship between the exhalation-to-inhalation sound pressure ratio in the low frequency range between 100 and 195 Hz (E/I LF) and the respiratory cycle dependence of impulse oscillometry (IOS) parameters. Methods Asthma patients underwent IOS [resistance of the respiratory system at 5 Hz (R5) and 20 Hz (R20), the reactance area (AX), resonant frequency of reactance (Fres), and reactance of the respiratory system at 5 Hz (X5) ], spirography, and an LSA. The correlation between the LSA-derived E/I LF values and the respiratory cycle dependence of the IOS parameters was analyzed. Patients Thirty-four patients with mild to moderate bronchial asthma, who had not received oral or inhaled corticosteroids and who had no episodes of rumbling or wheezing were examined. Results The E/I LF value was significantly correlated with the differences of the R5 and R5-R20 values between exhalation and inhalation (p=0.035 and p=0.050) in a multivariate analysis. Conclusion E/I LF appears to be an index that expresses the respiratory cycle dependence of asthma as well a...Continue Reading

References

Oct 1, 1975·The Journal of Allergy and Clinical Immunology·H ChaiR G Townley
Apr 1, 1988·The American Review of Respiratory Disease·B E ShykoffH K Chang
Dec 17, 2008·The Journal of Allergy and Clinical Immunology·Gary L LarsenUNKNOWN Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute
Oct 17, 2009·The Open Respiratory Medicine Journal·Meirav YosefYael A Glickman
Oct 4, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Arun NairBrian J Lipworth
Dec 20, 2011·The Journal of Allergy and Clinical Immunology·Yixin ShiSteven C George
Jun 23, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Yukio Nagasaka
Dec 3, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Terufumi ShimodaTomoaki Iwanaga
Jun 18, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Terufumi ShimodaTomoaki Iwanaga
Aug 16, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Terufumi ShimodaTomoaki Iwanaga

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