Lung squamous cell carcinoma mRNA expression subtypes are reproducible, clinically important, and correspond to normal cell types.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Matthew D WilkersonD Neil Hayes

Abstract

Lung squamous cell carcinoma (SCC) is clinically and genetically heterogeneous, and current diagnostic practices do not adequately substratify this heterogeneity. A robust, biologically based SCC subclassification may describe this variability and lead to more precise patient prognosis and management. We sought to determine if SCC mRNA expression subtypes exist, are reproducible across multiple patient cohorts, and are clinically relevant. Subtypes were detected by unsupervised consensus clustering in five published discovery cohorts of mRNA microarrays, totaling 382 SCC patients. An independent validation cohort of 56 SCC patients was collected and assayed by microarrays. A nearest-centroid subtype predictor was built using discovery cohorts. Validation cohort subtypes were predicted and evaluated for confirmation. Subtype survival outcome, clinical covariates, and biological processes were compared by statistical and bioinformatic methods. Four lung SCC mRNA expression subtypes, named primitive, classical, secretory, and basal, were detected and independently validated (P < 0.001). The primitive subtype had the worst survival outcome (P < 0.05) and is an independent predictor of survival (P < 0.05). Tumor differentiation and ...Continue Reading

References

Feb 1, 1996·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C W WuenschellD Warburton
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·C M PerouD Botstein
Aug 30, 2000·Nature·C M PerouD Botstein
Nov 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E GarberI Petersen
Mar 14, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hirsh KoyiEva Brandén
Apr 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Thomas J MarianiSteven D Shapiro
May 16, 2002·Histopathology·P G Chu, L M Weiss
Apr 22, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ann-Marie BroomeRichard L Eckert
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Jul 12, 2003·Bioinformatics·Jung Kyoon ChoiOok Joon Yoo
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Avrum SpiraJerome S Brody
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Feb 24, 2006·Nature Reviews. Cancer·Michael L WhitfieldCharles M Perou
Aug 31, 2006·Methods in Enzymology·Jeremy Gollub, Gavin Sherlock
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D Neil HayesMatthew Meyerson
Nov 4, 2006·Carcinogenesis·Jill Everland LarsenKwun Meng Fong
Apr 7, 2007·American Journal of Respiratory Cell and Molecular Biology·Andrea J RossRobert B Devlin
May 5, 2007·Molecular Carcinogenesis·Kathryn E King, Wendy C Weinberg
Aug 28, 2007·Bioinformatics·Matthew E RitchieGordon K Smyth
Sep 18, 2007·Biostatistics·Elizabeth Garrett-MayerEdward Gabrielson
Aug 16, 2008·American Journal of Respiratory Cell and Molecular Biology·Anthony J FischerPaul B McCray
Sep 23, 2008·Trends in Cell Biology·Shirley Polager, Doron Ginsberg
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eung-Sirk LeeJhingook Kim
Nov 29, 2008·The Journal of Pathology·J C SnyderB R Stripp
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul RoepmanNico van Zandwijk
Aug 8, 2009·Nature Medicine·Aleix Prat, Charles M Perou
Apr 30, 2010·Bioinformatics·Matthew D Wilkerson, D Neil Hayes

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Citations

Sep 3, 2013·Current Treatment Options in Oncology·Thomas E Stinchcombe
Sep 11, 2012·Nature·UNKNOWN Cancer Genome Atlas Research Network
Sep 15, 2012·Open Biology·Marie-Liesse Asselin-Labat, Caitlin E Filby
Nov 1, 2013·Science Translational Medicine·UNKNOWN Clinical Lung Cancer Genome Project (CLCGP), UNKNOWN Network Genomic Medicine (NGM)
Oct 3, 2013·PloS One·Yuji NakadaDiego H Castrillon
Apr 23, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Seon-Sook HanYeon-Mok Oh
Jun 25, 2014·Nature Reviews. Urology·Woonyoung ChoiDavid J McConkey
Aug 12, 2014·Der Pathologe·A WarthW Weichert
Feb 3, 2016·Scientific Reports·Arvind Singh MerMattias Rantalainen
Sep 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qing-Sheng ZhaoJing Liu
Mar 27, 2015·Stem Cells International·Feng LiXiaoming Liu
May 3, 2012·Seminars in Cancer Biology·Zafira CastañoSandra S McAllister
Aug 28, 2014·Scientific Reports·Yasin ȘenbabaoğluJun Z Li
Mar 18, 2015·IEEE Journal of Biomedical and Health Informatics·Jianting ShengStephen T C Wong
Jul 15, 2015·The Journal of Thoracic and Cardiovascular Surgery·Ruben PioLuis M Montuenga
Sep 10, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Larissa A PikorWan L Lam
Sep 6, 2013·The International Journal of Biochemistry & Cell Biology·Xin WangLouis Vermeulen
May 25, 2013·The Journal of Molecular Diagnostics : JMD·Matthew D WilkersonPhilip S Bernard
Sep 17, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ni ZhaoD Neil Hayes
Jan 15, 2015·Cellular Oncology (Dordrecht)·Cristina SantosRamon Salazar
Jun 28, 2014·Nucleic Acids Research·Matthew D WilkersonD Neil Hayes
Nov 9, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Xin LuoGuanghua Xiao
Mar 28, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hawazin FarukiMyla Lai-Goldman

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