Lung structure and function of infants with recurrent wheeze when asymptomatic.

The European Respiratory Journal
C J LlapurR S Tepper

Abstract

Infants with recurrent wheeze have repeated episodes of airways obstruction; however, relatively little is known about the structure and function of their lungs when not symptomatic. The current authors evaluated whether infants with recurrent wheeze have smaller airway lumens or thickened airway walls, as well as decreased airway function. High-resolution computed tomography images 1 mm thick were obtained at three anatomic locations at an elevated lung volume and at functional residual capacity. Forced expiratory flows were also measured in subjects with recurrent wheeze. Airway lumen, wall areas and lung tissue density were not significantly different for recurrent wheeze (n = 17) and control (n = 14) subjects; however, subjects with recurrent wheeze had lower forced expiratory flows than predicted. Similar findings were obtained when subjects were grouped by exposure to tobacco smoke. These findings indicate that infants with recurrent wheeze, as well as exposure to tobacco smoke, have lower airway function when not symptomatic. The lower forced expiratory flows may result from a degree of airway narrowing that could not be resolved with the methodology employed or from other mechanisms, such as more collapsible airways or ...Continue Reading

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Citations

Apr 24, 2013·Annals of the American Thoracic Society·Margaret RosenfeldUNKNOWN American Thoracic Society Assembly on Pediatrics Working Group on Infant and Preschool Lung Function Testing
Apr 10, 2010·American Journal of Respiratory and Critical Care Medicine·Joseph FawkeJanet Stocks
Dec 7, 2017·Pediatric Pulmonology·Philip K PattemoreUNKNOWN New Zealand Asthma and Allergy Cohort Study Group
Jun 17, 2018·Thorax·Zihang LuPadmaja Subbarao

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