Lung tissue resistance in diffuse interstitial pulmonary fibrosis

The Journal of Clinical Investigation
H Bachofen, M Scherrer

Abstract

1) Measured during spontaneous breathing in ten patients with diffuse interstitial lung disease, total pulmonary resistance averaged 3.53 +/- 1.56 cm H(2)O per L per second; airway resistance, 1.63 +/- 0.79 cm H(2)O per L per second; and lung tissue resistance, 1.90 +/- 0.95 cm H(2)O per L per second (range, 0.89 to 3.96). The lung tissue resistance was on an average about four times higher in patients with lung fibrosis than in ten healthy persons of the same age. No significant difference in airway resistance was found between healthy subjects and patients.2) In three patients the lung tissue resistance was measured during spontaneous breathing and during panting. Much higher values were found during spontaneous breathing.3) In patients with lung fibrosis and also in healthy subjects, there seems to have been an inverse correlation between the vital capacity, or the compliance, on the one hand, and the lung tissue resistance on the other. Nevertheless, in patients with lung fibrosis the lung tissue resistance was more increased than could be attributed to the loss of normally compliant lung tissue only.4) No correlation was found between the lung tissue resistance and severity of impairment of pulmonary gas exchange; especial...Continue Reading

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Citations

Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·M DolhnikoffM S Ludwig
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·T EbiharaM S Ludwig
Sep 1, 1977·The Journal of Clinical Investigation·J D FulmerR G Crystal
Aug 25, 2010·The Journal of Cell Biology·Fei LiuDaniel J Tschumperlin
Dec 23, 2014·Experimental Lung Research·Louise OrganKen Snibson
Jul 22, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Norbert Berend
Sep 17, 2013·Computers in Biology and Medicine·Grzegorz Redlarski, Jacek Jaworski
Jul 9, 2009·Physiological Reviews·Débora S Faffe, Walter A Zin
Aug 23, 2020·International Journal of Molecular Sciences·Brittany N SzafranAlexandra Noël

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