Lung toxicity associated with cyclophosphamide use. Two distinct patterns

American Journal of Respiratory and Critical Care Medicine
S W MalikU Specks

Abstract

Cyclophosphamide-induced lung toxicity may be difficult to recognize because of the presence of confounding variables such as concomitant use of other cytotoxic drugs, opportunistic infections, diffuse pulmonary malignancy, radiation pneumonitis, and oxygen toxicity. The purpose of this retrospective analysis was to identify the clinical spectrum of pulmonary toxicity of cyclophosphamide. In our review of case records, we sought to identify patients in whom cyclophosphamide was the only identifiable etiologic factor for lung toxicity. In a 20-yr period six patients were identified with cyclophosphamide-induced lung disease, including five men and one woman ranging in age from 42 to 78 yr. Clinical features of toxicity include dyspnea, fever, cough, new parenchymal infiltrates, gas exchange abnormalities on pulmonary function tests, and pleural thickening on chest roentgenogram. Two patterns of cyclophosphamide-induced lung toxicity were identified. A single patient presented with early-onset pneumonitis and responded to discontinuation of the drug. Five patients with late-onset pneumonitis developed progressive pulmonary fibrosis associated with bilateral pleural thickening. Patients with late-onset pneumonitis showed no respon...Continue Reading

Citations

Jun 16, 2012·Zeitschrift für Rheumatologie·J O SchröderM Both
Dec 1, 2012·Inflammopharmacology·Ghada M SuddekNariman M Gameil
Nov 5, 2013·Revue de pneumologie clinique·L Essaadouni, L Benjilali
Oct 17, 1998·Biochemical Pharmacology·N VenkatesanG Chandrakasan
Oct 21, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·O A MinaiS Kesten
Jan 14, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R YerushalmiS M Stemmer
May 16, 2000·Critical Care Medicine·E Rosenow
Sep 19, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jorge Brieva
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·C FuhrmanJ Cadranel
Sep 19, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·S E RossiP C Goodman
Jun 16, 2014·Breast Cancer Research and Treatment·Claudia OmariniStephen R D Johnston
Nov 5, 2015·Paediatric Respiratory Reviews·A Birgitta Versluys, Dorine Bresters
Jan 12, 2008·Chest·Jeffrey J SwigrisKevin K Brown
Mar 19, 2011·Chest·Tseng-Tien HuangKirsten K Ness
Jan 20, 2016·Internal Medicine·Tomoya IshiiHiroyasu Yokomise
Oct 30, 2012·Immunology and Allergy Clinics of North America·Amy L OlsonAryeh Fischer
Oct 30, 2012·Immunology and Allergy Clinics of North America·Keith C Meyer, Jennifer Bierach
Jul 29, 1999·Chest·S Y Morelock, S A Sahn
Oct 28, 2011·Revista española de geriatría y gerontología·Sonia MiguélezMaría José Fernández-Reyes
Aug 10, 2010·Clinics in Chest Medicine·Faye N HantRichard M Silver
Aug 10, 2010·Clinics in Chest Medicine·Meena Kalluri, Chester V Oddis
Aug 10, 2010·Clinics in Chest Medicine·Keith C MeyerRobert Baughman
Aug 20, 2016·Nuclear Medicine and Molecular Imaging·Sameer Kamalakar TaywadeChandrasekhar Bal
Jul 14, 2009·Best Practice & Research. Clinical Rheumatology·José María Pego-ReigosaDavid A Isenberg
Apr 28, 2006·Clinical Lymphoma & Myeloma·Yair HerishanuElizabeth Naparstek
May 24, 2006·Clinics in Chest Medicine·Michael A Jantz, Veena B Antony
Jul 17, 2004·International Journal of Experimental Pathology·Mark HirshMichael M Krausz
Jun 18, 2009·American Journal of Industrial Medicine·Giuseppe MastrangeloJohn H Lange
Sep 25, 2012·Arthritis Care & Research·Megan L KrauseVaidehi R Chowdhary
Dec 23, 2014·International Journal of Rheumatic Diseases·Shoichi FukuiTsunekazu Hishima
Sep 1, 2001·Critical Care Clinics·C Shanholtz
Nov 29, 2001·Rheumatic Diseases Clinics of North America·J H StoneD B Hellmann
Jan 30, 2002·Radiologic Clinics of North America·Jeremy J ErasmusSantiago E Rossi
Aug 28, 2004·Clinics in Chest Medicine·Philippe CamusPascal Foucher
Aug 19, 2015·International Journal of Radiation Oncology, Biology, Physics·Daniel M GreenAmar Gajjar

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