Lung toxicity due to thalidomide

Archivos de bronconeumología
F Carrión Valero, V Bertomeu González

Abstract

Although the side effects of thalidomide are well known, lung toxicity has not been reported. We describe the case of a 65-year-old man with multiple myeloma (IgG kappa) in stage IA who, on the thirty-seventh day of treatment with thalidomide, developed acute coughing, general malaise, dyspnea at rest and sudoresis. Blood pressure was 90/60 mm Hg and temperature was normal. An interstitial and alveolar pattern was visible on the right side of a chest film and arterial blood gases indicated partial respiratory insufficiency (pH 7.40, PaCO2 40 mmHg, PaO2 47 mmHg). Blood analysis showed alterations expected for multiple myeloma and microbiology was negative (sputum and blood cultures and urinary antigen detection for Streptococcus pneumoniae and Legionella pneumophila). After thalidomide was withdrawn and oxygen and intravenous corticoids were administered, outcome was good. A chest film 4 days later was normal and arterial blood gases showed that respiratory insufficiency had disappeared. We conclude that severe lung toxicity should be included among the potential adverse effects of thalidomide.

Citations

Jan 2, 2007·Southern Medical Journal·Ashley A FeaverVincent Mysliwiec
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Masahiro OnozawaMasahiro Asaka
Aug 6, 2003·Pharmacoepidemiology and Drug Safety
Apr 7, 2005·The Annals of Pharmacotherapy·Mary E Gordinier, Don S Dizon
Sep 10, 2008·Cases Journal·Lisa TilluckdharryMuzaffar Ahmad
Dec 24, 2010·The Korean Journal of Internal Medicine·Myung-Hee KangGyeong-Won Lee

Related Concepts

Coughing
Dyspnea
Immunosuppressive Agents
Lung
Multiple Myeloma
Respiration Disorders
Respiratory Failure
Thalomid
Radiography, Thoracic

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