Lung transplant patients' T cell responses to influenza vaccine viruses between seasons

Vaccine
Mary S HayneyWilliam J Burlingham

Abstract

We hypothesized that T cell responses to influenza viruses by lung transplant and healthy individuals would be similar. Twelve lung transplant patients and 12 healthy individuals received influenza vaccines during two seasons. Lymphocytes were isolated for the trans-vivo delayed-type hypersensitivity assay from blood samples following immunization. T cell responses to all three inactivated influenza antigens from each were similar between the groups. However, the response to the A/New Caledonia (H1N1) virus by transplant patients was greater than the healthy controls' response, but only in the first season. The magnitude of the T cell responses in lung transplant patients is similar to those of healthy control individuals. These responses may be important in T cell memory.

References

Feb 1, 1987·Transplantation·W E BeyerW Weimar
Aug 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P LjungmanO Weiland
Feb 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E A BlumbergF G Hayden
Aug 10, 1999·Human Immunology·L CarrodeguasA M VanBuskirk
Mar 17, 1997·The American Journal of Medicine·C H Wendt
Jul 6, 2000·The Journal of Clinical Investigation·A M VanBuskirkC G Orosz
Dec 12, 2001·Vaccine·M S HayneyJ A Bianco
Feb 7, 2002·The European Respiratory Journal·P J MazzoneJ R Maurer
Jul 15, 2003·Clinical Microbiology Reviews·Andrea DuchiniPaul J Pockros
Nov 15, 2003·Journal of Clinical Pharmacology·Mary S Hayney, Daniel Muller
Oct 13, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Peter J MazzoneJanet R Mauer
Jan 25, 2005·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Mary S HayneyRobert B Love
Aug 29, 2007·Pharmacotherapy·Mary S HayneyWilliam J Burlingham

❮ Previous
Next ❯

Citations

Apr 1, 2010·Seminars in Respiratory and Critical Care Medicine·Pali Dedhiya Shah, John F McDyer
Jun 19, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Benjamin Daniel FoxMordechai R Kramer
Oct 1, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D KumarUNKNOWN AST Infectious Diseases Community of Practice
Dec 25, 2009·Pharmacotherapy·Orly VardenyMary S Hayney
Oct 27, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lara A Danziger-IsakovUNKNOWN ISHLT Infectious Diseases Council
Jan 16, 2015·The Journal of Infectious Diseases·Adrian EgliDeepali Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved