Lung transplantation for cystic fibrosis.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Jonathan C YeungS Keshavjee

Abstract

The contribution of lung transplantation to the treatment of patients with end-stage cystic fibrosis (CF) has been debated. We aimed to describe achievable outcomes from high-volume CF and lung transplant programs. This study reports on the largest single-center experience of lung transplantation for adult and pediatric patients with CF. It also highlights the evolution of practice and outcomes over time. A retrospective analysis of the prospectively collected Toronto Lung Transplant database was carried out. Post-transplant survival in CF was calculated using the Kaplan-Meier method and analyzed with log-rank tests. From 1983 to 2016, a total of 1,885 transplants were performed at our institution, where 364 (19.3%) were CF recipients and another 39 (2.1%) were CF retransplants. The mean age at first transplant was 29.5 ± 9.7 years where 56.6% were males and 91.5% were adults. Pre-transplantation, 88 patients (24.2%) were Burkholderia cepacia complex (BCC)-positive, 143 (39.3%) had diabetes mellitus, and the mean forced expiratory volume in one second was 26.0 ± 7.2%, as predicted at listing. The 1-, 5-, and 10-year probabilities of survival in adults who were BCC-negative were 94%, 70%, and 53%, respectively. Pediatric, BCC-po...Continue Reading

Citations

May 30, 2020·Journal of Thrombosis and Haemostasis : JTH·Siobhan Branfield, A Valance Washington
Oct 28, 2020·Expert Review of Respiratory Medicine·Lorena van den BogaartOriol Manuel
Oct 25, 2020·Clinical Transplantation·Raphael Werner, Christian Benden
Jan 12, 2021·Expert Opinion on Drug Delivery·Douweh Leyla Gbian, Abdelwahab Omri
Feb 20, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Mustafa VayvadaErdal Tasci
May 25, 2021·Seminars in Respiratory and Critical Care Medicine·Alicia B Mitchell, Allan R Glanville
Oct 22, 2021·Pediatric Pulmonology·Kimberly A McBennettMichael W Konstan

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