Lung transplantation for pulmonary sarcoidosis. Twenty-five years of experience in the USA

Thorax
Ziad TaimehMarc Pritzker

Abstract

Lung transplantation is the ultimate treatment for end-stage pulmonary sarcoidosis. Post-transplant survival outcomes remain unclear. Survival models were used to assess survival and graft outcomes in patients with sarcoid among 20,896 lung transplants performed in the USA. 695 lung recipients were transplanted for pulmonary sarcoidosis. Sarcoid lung recipients had similar median survival rate (69.7 months (IQR 60.2-79.3)) compared with the non-sarcoid lung recipients (63.1 months (IQR 61.4-64.8), p=0.88). In multivariate Cox regression, sarcoidosis was not independently associated with worse mortality (HR 0.96 (95% CI 0.85 to 1.08), p=0.51). Among the sarcoid lung recipients, double lung transplantation (HR 0.76 (0.58 to 0.99), p=0.04) and lung allocation score era (HR 0.74 (0.56 to 0.97), p=0.03) were associated with improved survival. Recipients of lung transplants for pulmonary sarcoidosis had similar outcomes compared with non-sarcoid lung recipients.

References

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Aug 17, 2014·BMC Pulmonary Medicine·Kristin D KistlerDirk Esser

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Citations

Aug 15, 2019·Therapeutic Advances in Respiratory Disease·Shambhu Aryal, Steven D Nathan
Aug 3, 2020·Current Opinion in Pulmonary Medicine·Divya C Patel, Dominique Valeyre
Jul 24, 2020·Current Opinion in Pulmonary Medicine·Laurens J De SadeleerGeert M Verleden
Aug 11, 2020·Seminars in Respiratory and Critical Care Medicine·Rohit Gupta, Robert P Baughman
May 16, 2019·Expert Opinion on Pharmacotherapy·Marta LlabresJacobo Sellares
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Sep 7, 2016·Deutsches Ärzteblatt International·Antje Prasse
Dec 4, 2020·Thorax·Muhunthan ThillaiAthol U Wells
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Jun 19, 2021·Pulmonary Therapy·Andrea S MelaniElena Bargagli
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Jan 23, 2021·The European Respiratory Journal·Jérôme Le PavecJens Gottlieb

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