Abstract
Lung transplantation for pulmonary failure resulting from systemic disease is controversial. We reviewed our transplant experience in patients with sarcoidosis, scleroderma, lymphangioleiomyomatosis, and graft-versus-host disease. This retrospective review examined the outcome of 23 patients who underwent pulmonary transplantation for these systemic diseases. Group 1 included 15 patients with pulmonary hypertension who underwent transplantation (9 for sarcoidosis, 6 for scleroderma), and group 2 included 8 patients with normal pulmonary artery pressures who underwent transplantation (5 for lymphangioleiomyomatosis, 3 for graft-versus-host disease). The incidences of infection and rejection, pulmonary function, and survival were measured and compared with those of patients who underwent transplantation for isolated pulmonary disease. Although there were no differences in the rate of infection between patients who underwent transplantation for systemic versus isolated disease, patients with pulmonary hypertension who underwent transplantation for systemic disease had significantly lower rates of rejection. Four patients with sarcoidosis and 2 with lymphangioleiomyomatosis demonstrated recurrence in the allograft. Survival was sim...Continue Reading
References
Sep 1, 1992·Chest·J H CalhoonJ K Trinkle
Mar 1, 1992·Journal of Thoracic Imaging·A C ArroligaR A Matthay
Mar 1, 1994·Chest·S M LevineC L Bryan
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·J D O'BrienE P Trulock
Oct 1, 1994·Chest·J C ErnstJ M Cary
Nov 1, 1994·The Annals of Thoracic Surgery·K BandoB P Griffith
Jul 1, 1994·The Annals of Thoracic Surgery·A el-GamelC J Campbell
Nov 1, 1993·The American Review of Respiratory Disease·B A JohnsonB P Griffith
Dec 1, 1993·The Annals of Thoracic Surgery·S SundaresanJ D Cooper
Citations
Sep 5, 2002·Arthritis and Rheumatism·M MaglianoJ Hillson
Apr 14, 1999·Comprehensive Therapy·H I Palevsky, I Gurughagavatula
Sep 7, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jacques KpodonuAlexander S Geha
Mar 17, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Taine T PechetG Alexander Patterson
Mar 20, 2002·Acta medica Austriaca·G H Stummvoll
Apr 8, 1999·The New England Journal of Medicine·S M Arcasoy, R M Kotloff
Nov 1, 2002·Current Opinion in Rheumatology·John Varga
Nov 1, 2002·Current Opinion in Rheumatology·Lionel Schachna, Fredrick M Wigley
Oct 5, 2001·Current Opinion in Pulmonary Medicine·R SulicaM L Padilla
Aug 12, 2005·Current Opinion in Pulmonary Medicine·Raed AlalawiTony N Hodges
Aug 30, 2008·Transplantation·Martine Reynaud-GaubertMarc Stern
Jan 22, 2005·Treatments in Respiratory Medicine·Allan Ramirez, John Varga
Oct 14, 2005·World Journal of Surgery·Malek G MassadAlexander S Geha
Nov 26, 2013·Rheumatic Diseases Clinics of North America·Saman Ahmed, Harold I Palevsky
Aug 22, 2015·Transplantation Proceedings·T NakagiriM Okumura
Sep 12, 2015·The Annals of Thoracic Surgery·Kazuhiro WakidaMasami Sato
Nov 23, 2006·Transplantation Proceedings·F ChenH Wada
Feb 13, 2009·Clinical Transplantation·David ShitritMordechai R Kramer
Sep 14, 2001·Chest·S M ArcasoyR M Kotloff
Jul 29, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ryujiro SugimotoYoshifumi Sano
Nov 30, 2006·Arthritis and Rheumatism·Lionel SchachnaAllan C Gelber
Sep 8, 2012·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Troy TakagishiRodney Tehrani
Aug 26, 1999·Current Opinion in Pulmonary Medicine·S NagaiT Izumi
Jul 14, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Anna E FrickKonrad Hoetzenecker