Lung transplantation in children and young adults: a 20-year single-centre experience

The European Respiratory Journal
Saskia GruberZsolt Szépfalusi

Abstract

Lung transplantation in adults is an accepted therapeutic option, whereas there is ongoing debate on its positive impact on survival in children. We report our experience of the first 20 yrs of paediatric lung transplantation at a single centre in Austria. Patient survival, organ survival and freedom from bronchiolitis obliterans were estimated by Kaplan-Meier curves. Pre- and post-transplant parameters were assessed and their influence on patient and organ survival evaluated by univariate tests and stepwise multivariate analyses. A total of 55 transplantations were performed in 43 patients. 1- and 5-yr patient survival rates were 72.1% and 60.6%, respectively, and 52.6% of patients were found to be free from bronchiolitis obliterans syndrome at 5 yrs post-transplant. Analysing different eras of transplantation suggests an improvement over the years with a 5-yr survival rate of 70.6% in the second decade. A positive effect of pre-transplant diabetes mellitus and immunosuppression was found with the newer drug tacrolimus, and a negative effect of pre-transplant in-hospital admission was reported. A high rate of successful re-transplantation prolonged total patient survival.

Citations

Feb 26, 2014·Revue de pneumologie clinique·V BoussaudF Le Pimpec Barthes
May 17, 2014·Acta Paediatrica·Jose A Castro-RodriguezPatricia Murtagh
Aug 5, 2015·Lung·Don HayesCarol K Conrad
Mar 22, 2016·Expert Review of Respiratory Medicine·Florian A Schmid, Christian Benden
Jun 20, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Anne L StephensonSanja Stanojevic
Jun 25, 2015·Frontiers in Pediatrics·Kelley L Colvin, Michael E Yeager
Nov 5, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Paula MorenoAngel Salvatierra
Jul 29, 2018·The Clinical Respiratory Journal·David DreesDon Hayes
Nov 16, 2016·Expert Review of Respiratory Medicine·Cecilia Chaparro, Shaf Keshavjee
Oct 25, 2020·Clinical Transplantation·Raphael Werner, Christian Benden

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