Lung tumour risk in radon-exposed rats from different experiments: comparative analysis with biologically based models

Radiation and Environmental Biophysics
J C KaiserC G Collier

Abstract

Data sets of radon-exposed male rats from Wistar and Sprague-Dawley strains have been investigated with two different versions of the two-step clonal expansion (TSCE) model of carcinogenesis. These so-called initiation-promotion (IP) and initiation-transformation (IT) models are named after the cell-based processes that are assumed to be induced by radiation. The analysis was done with all malignant lung tumours taken to be incidental and with fatal tumours alone. For all tumours treated as incidental, both models could explain the tumour incidence data equally well. Owing to its better fit, only the IP model was applied in the analysis of fatal tumours that carry additional information on the time when they cause death. A statistical test rejected the hypothesis that a joint cohort of Wistar and Sprague-Dawley rats can be described with the same set of model parameters. Thus, the risk analysis has been carried out for the Wistar rats and the Sprague-Dawley rats separately and has been restricted to fatal tumours alone because of their similar effect in humans. Using a refined technique of age-adjustment, the lifetime excess absolute risk has been standardised with the survival function from competing risks in the control popul...Continue Reading

References

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Sep 21, 2004·Radiation and Environmental Biophysics·W F HeidenreichG Monchaux

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Citations

Jul 5, 2012·Journal of Toxicology and Environmental Health. Part a·Ji-Hua NieJian Tong
Feb 5, 2008·Journal of Toxicology and Environmental Health. Part a·Nai-Yu XuJian Tong
Sep 21, 2004·Radiation and Environmental Biophysics·W F HeidenreichG Monchaux
May 3, 2005·Radiation and Environmental Biophysics·W F HeidenreichM Rosemann
Sep 28, 2005·Radiation and Environmental Biophysics·W F HeidenreichG Monchaux
Dec 22, 2007·Radiation and Environmental Biophysics·M P LittleD C Thomas
Nov 13, 2009·Radiation and Environmental Biophysics·Wolfgang F Heidenreich, H M Cullings
Dec 22, 2005·International Journal of Radiation Biology·C G CollierR Haylock
Jul 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sumanta Kumar Pal, Arti Hurria
Dec 19, 2009·Toxicologic Pathology·James E KlaunigBarbara A Hocevar
Jun 21, 2019·Radiation and Environmental Biophysics·Matthias AßenmacherHelmut Küchenhoff
Aug 28, 2020·Frontiers in Oncology·Xinying XueLei Pan

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