Lung vagal afferent activity in rats with bleomycin-induced lung fibrosis

Respiration Physiology
E S SchelegleA T Chen

Abstract

Bleomycin treatment in rats results in pulmonary fibrosis that is characterized by a rapid shallow breathing pattern, a decrease in quasi-static lung compliance and a blunting of the Hering-Breuer Inflation Reflex. We examined the impulse activity of pulmonary vagal afferents in anesthetized, mechanically ventilated rats with bleomycin-induced lung fibrosis during the ventilator cycle and static lung inflations/deflations and following the injection of capsaicin into the right atrium. Bleomycin enhanced volume sensitivity of slowly adapting stretch receptors (SARs), while it blunted the sensitivity of these receptors to increasing transpulmonary pressure. Bleomycin treatment increased the inspiratory activity, while it decreased the expiratory activity of rapidly adapting stretch receptors (RARs). Pulmonary C-fiber impulse activity did not appear to be affected by bleomycin treatment. We conclude that the fibrosis-related shift in discharge profile and enhanced volume sensitivity of SARs combined with the increased inspiratory activity of RARs contributes to the observed rapid shallow breathing of bleomycin-induced lung fibrosis.

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Citations

May 17, 2011·Respiratory Physiology & Neurobiology·Frank J JaconoThomas E Dick
Jul 17, 2013·Respiratory Physiology & Neurobiology·Frank J Jacono
Sep 7, 2005·Respiratory Physiology & Neurobiology·Jerry Yu
Sep 15, 2016·Journal of Neurotrauma·Kun-Ze Lee, Hsiang-Chun Kuo
Oct 15, 2011·Respiration; International Review of Thoracic Diseases·Phillipa L MiltonRebecca Lim
Dec 21, 2002·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Edward S Schelegle
Aug 5, 2006·Journal of Applied Physiology·F J JaconoN R Prabhakar
Nov 22, 2001·Journal of Applied Physiology·F J GolderD C Bolser

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