Lung volume and expiratory flow rates from pre- to post-puberty

European Journal of Applied Physiology
Joshua R SmithCraig A Harms

Abstract

The purpose was to determine if the airways and lungs grow disproportionately from pre- to post-puberty in boys and girls. We hypothesized that the airways grow at a slower rate than lung volume (i.e. dysanapsis growth) during puberty and boys would exhibit more dysanaptic growth compared to girls. Twenty-one pre-pubescent children [11 boys (pre 10.1 ± 0.5 years, post 15.3 ± 0.5 years); 10 girls (pre 9.4 ± 1.0 years, post 14.1 ± 1.0 years)] performed pulmonary function tests (PFTs) ~5 years ago from an original cohort of 40 children. These 21 children performed PFTs, which included forced vital capacity (FVC) and forced expiratory flow at 50 % FVC (FEF50). Static pressure at 50 % of FVC [Pst(L)50 %] was estimated based on age. Dysanapsis ratio (DR) was calculated [FEF50 × FVC(-1) × Pst(L) 50 % (-1) ]. Maturation status was determined via Tanner stages. Stage of maturation was not different (p > 0.05) between boys and girls (4.2 ± 0.6 stage vs. 3.7 ± 0.7 stage, respectively). FVC and FEF50 increased (p < 0.05), DR significantly decreased, and FEF50/FVC was similar (p > 0.05) from pre- to post-puberty. FEF50 and FVC significantly increased and DR decreased (p < 0.05) post-puberty for both sexes. Post-puberty, boys had a significa...Continue Reading

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Citations

Sep 24, 2015·High Altitude Medicine & Biology·Charles A Weitz, Ralph M Garruto
Apr 9, 2017·Thorax·Gregory S Montgomery, Stephanie D Davis
May 21, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Adetola KoleadeZhiwei Gao
Feb 27, 2020·Medicine and Science in Sports and Exercise·Katherine R CoxStephanie P Kurti
Feb 15, 2019·Frontiers in Physiology·Paolo T Pianosi, Joshua R Smith
Oct 20, 2018·Pediatric Exercise Science·Paolo T Pianosi
Jan 2, 2021·Wellcome Open Research·Navya MishraAnurag Agrawal
Mar 6, 2021·Pediatric Pulmonology·Christopher HarrisAnne Greenough
Jul 7, 2021·International Journal of Clinical Practice·Walid Al-Qerem

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