Lungtech, a phase II EORTC trial of SBRT for centrally located lung tumours - a clinical physics perspective

Radiation Oncology
Marie LambrechtCoen W Hurkmans

Abstract

The EORTC has launched a phase II trial to assess safety and efficacy of SBRT for centrally located NSCLC: The EORTC 22113-08113-Lungtech trial. Due to neighbouring critical structures, these tumours remain challenging to treat. To guarantee accordance to protocol and treatment safety, an RTQA procedure has been implemented within the frame of the EORTC RTQA levels. These levels are here expanded to include innovative tools beyond protocol compliance verification: the actual dose delivered to each patient will be estimated and linked to trial outcomes to enable better understanding of dose related response and toxicity. For trial participation, institutions must provide a completed facility questionnaire and beam output audit results. To insure ability to comply with protocol specifications a benchmark case is sent to all centres. After approval, institutions are allowed to recruit patients. Nonetheless, each treatment plan will be prospectively reviewed insuring trial compliance consistency over time. As new features, patient's CBCT images and applied positioning corrections will be saved for dose recalculation on patient's daily geometry. To assess RTQA along the treatment chain, institutions will be visited once during the t...Continue Reading

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Citations

May 23, 2016·The Journal of Thoracic and Cardiovascular Surgery·Gaetano Rocco
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Methods Mentioned

BETA
surgical resection
biopsy

Software Mentioned

EORTC RTQA platform
SUP
INF
RT
DICOM
[UNK]
RTQA

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