Lupane triterpenes with a carbonyl group at C-20 induce cancer cell apoptosis.

Journal of Natural Medicines
Keishi HataYasuo Fujimoto

Abstract

We evaluated the effects of various lupane triterpenes on B16 2F2 mouse melanoma cell differentiation and proliferation. All of the compounds tested (numbered 1-6) induced melanogenesis of B16 2F2 cells, a marker of melanoma cell differentiation. Compounds 4-6, which have a carbonyl group at C-20, markedly inhibited the growth of B16 2F2 cells by the induction of apoptosis. Cytotoxic profiles of these lupane triterpenes against human cancer cells demonstrated that compounds 4-6 showed inhibitory effects on the proliferations of leukemia and lung cancer cells, to a greater extent than other cancer and normal fibroblast cells. These results suggest that the carbonyl group at C-20 of lupane triterpenes played important roles in their apoptosis-inducing activity against cancer cells.

References

Jul 17, 1999·Biological & Pharmaceutical Bulletin·M TakasakiH Ageta
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May 2, 2003·Phytotherapy Research : PTR·Young-Jae YouByung-Zun Ahn
Feb 3, 2007·Chemical & Pharmaceutical Bulletin·Shoujiro OgawaTakashi Iida

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Citations

Dec 10, 2016·Pharmaceutical Biology·Peik Lin TeohBo Eng Cheong
Mar 18, 2020·Natural Product Research·Vanessa Rocha MachadoMaria Cláudia Santos-Silva
May 27, 2015·The Journal of Organic Chemistry·Izabella JastrzębskaJacek W Morzycki
Apr 3, 2012·Journal of Natural Products·Fátima Gutiérrez-NicolásPedro Joseph-Nathan

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